Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: N-Acetyl-L-cysteine
Abbreviation: NAC
Alias: Acetylcysteine
CAS No.: 616-91-1
Molecular Formula: C5H9NO3S
Molecular Weight: 163.19
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Slight sulfur odor, sour taste
- Solubility: Freely soluble in water and ethanol; slightly soluble in methanol; insoluble in chloroform, ether and aliphatic hydrocarbons
- Melting Point: 106–109 °C
- Specific Rotation: [α]D2? +21° ~ +27° (c=1, ethanol)
- Hygroscopicity: Slightly hygroscopic under high humidity
- Aqueous solution property: Aqueous solution shows weak acidity, easy to oxidize when exposed to air
Chemical Properties
- Molecular structure: L-cysteine derivative with acetyl group on amino terminal, contains free active thiol (-SH) group
- Antioxidant characteristic: Thiol group scavenges free radicals, replenishes intracellular glutathione
- Mucolytic activity: Breaks disulfide bonds in mucus protein to dilute thick sputum
- Oxidation reaction: Easily oxidized by oxygen to form N,N'-diacetyl-L-cystine disulfide dimer
- Acylation & condensation: Amino and carboxyl groups can participate in esterification and amidation reactions
- Thermal stability: Stable below 80 °C; accelerated oxidation and decomposition at high temperature
- Compatibility: Compatible with neutral polar solvents; incompatible with strong oxidants, heavy metal ions and alkaline long-term storage
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Mucolytic drug for respiratory diseases with thick phlegm such as bronchitis and pneumonia
- Specific antidote for acetaminophen overdose poisoning
- Raw material for oral granules, effervescent tablets and inhalation solution
2. Functional Health Food Raw Material
Antioxidant nutritional additive for anti-aging, liver protection and immunity-improving dietary supplements
3. Cosmetic Active Ingredient
Skin brightening antioxidant, improves skin dullness, inhibits melanin formation, repairs oxidative damage
4. Biochemical Laboratory Reagent
Reducing agent for protein denaturation, disulfide bond cleavage in electrophoresis and cell culture medium additive
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 616-91-1 |
| Molecular Formula | C5H9NO3S |
| Molecular Weight | 163.19 |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | 25kg PE-lined fiber drum, nitrogen-filled amber aluminum foil vacuum bag |
| Storage Condition | Hermetic, light-proof dry warehouse below 25 °C; isolate air and oxidants to avoid oxidation |
| Transportation Requirement | Thiol-containing amino acid solid, sealed moisture-proof and oxygen-proof packaging |
| Shelf Life | 24 months under intact nitrogen-filled vacuum packaging |
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