Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Acetylsalicylic Acid
Alias: Aspirin, 2-Acetoxybenzoic acid
CAS No.: 50-78-2
Molecular Formula: C9H8O4
Molecular Weight: 180.16
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline needle powder
- Odor: Faint acetic acid odor, slight sour taste
- Solubility: Slightly soluble in cold water, soluble in hot water, ethanol, methanol, chloroform; insoluble in alkane solvents
- Melting Point: 135–136 °C
- Hygroscopicity: Slightly hygroscopic; moisture accelerates hydrolysis
- Crystal morphology: Slender needle crystals recrystallized from hot water
Chemical Properties
- Molecular structure: Benzoic acid derivative with acetyl ester group on ortho phenolic hydroxyl
- Hydrolysis reaction: Breaks down into salicylic acid and acetic acid under humid, hot or alkaline conditions
- Acid property: Weak organic acid, reacts with alkali metals to form soluble acetylsalicylate salts
- Color reaction: Hydrolysis-generated salicylic acid turns purple when mixed with ferric ion solution
- Thermal stability: Stable below 100 °C; high temperature triggers ester hydrolysis and sublimation
- Compatibility: Compatible with neutral pharmaceutical excipients; incompatible with strong alkalis, heavy metal salts and moisture-rich environments
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Classic NSAID with analgesic, antipyretic and anti-inflammatory effects for fever, headache, joint pain and rheumatism
- Low-dose tablet raw material for anti-platelet aggregation to prevent cardiovascular thrombosis
- Raw material for oral tablets, effervescent tablets and compound cold medicine preparations
2. Cosmetic Raw Material Intermediate
Precursor for mild exfoliating skincare actives after controlled hydrolysis
3. Analytical Reference Standard
HPLC calibration standard for salicylic acid and acetylsalicylic acid detection in pharmaceutical preparations
4. Organic Synthetic Building Block
Raw material for synthesis of other salicylate derivatives and fine chemical intermediates
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 50-78-2 |
| Molecular Formula | C9H8O4 |
| Molecular Weight | 180.16 |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Grade ≥99.5%; Reference Standard ≥99.9% |
| Water Content (KF) | ≤0.30% |
| Free Salicylic Acid | ≤0.1% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | 25kg PE-lined fiber drum, nitrogen-filled aluminum foil vacuum bag |
| Storage Condition | Hermetic, dry warehouse below 25 °C; strictly isolate moisture to avoid hydrolysis |
| Transportation Requirement | Pharmaceutical raw material solid, moisture-proof sealed packaging |
| Shelf Life | 36 months under intact sealed packaging |
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