Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Glycyl-L-Histidyl-L-Lysine
Abbreviation: GHK
Alias: Glycylhistidyllysine, Copper peptide free ligand
CAS No.: 49557-75-7
Molecular Formula: C14H24N8O4
Molecular Weight: 368.39
2. Physical and Chemical Properties
Physical Properties
- Appearance: White or off-white crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water; soluble in methanol; slightly soluble in ethanol; insoluble in acetone, chloroform, hexane and other non-polar solvents
- Aqueous solution pH: Weakly acidic
- Hygroscopicity: Slightly hygroscopic under high humidity environment
- Optical activity: Natural L-type tripeptide with optical rotation characteristic
Chemical Properties
- Molecular structure: Linear tripeptide composed of glycine, L-histidine and L-lysine linked by peptide bonds; contains imidazole group, amino side chain and terminal carboxyl group
- Metal chelation: Strong chelating ability with copper ion to form GHK-Cu complex
- Hydrolysis characteristic: Degraded into three single amino acids under strong acid, strong alkali or high-temperature protease environment
- Antioxidant activity: Scavenges reactive oxygen free radicals, inhibits oxidative damage of cells
- Thermal stability: Stable below 60 °C; long-term heating above 80 °C accelerates peptide bond hydrolysis
- Compatibility: Compatible with most cosmetic raw materials and aqueous excipients; incompatible with strong oxidants, heavy metal precipitants and strong alkaline conditions
3. Main Application Fields
1. Cosmetic Active Ingredient (Core Application)
- Anti-aging skin care additive: Promotes collagen and elastin synthesis, repairs fine lines, tightens skin
- Repair ingredient for sensitive skin, improves skin barrier, relieves redness and dullness
- Hair care raw material to activate scalp follicles and reduce hair loss
2. Biochemical Research Reagent
- Cell culture additive for skin fibroblast proliferation experiments
- Standard ligand for copper chelation and metal ion transport mechanism research
3. Pharmaceutical Research Raw Material
Research intermediate for wound repair, anti-inflammatory and tissue regeneration drug development
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 49557-75-7 |
| Molecular Formula | C14H24N8O4 |
| Molecular Weight | 368.39 |
| Appearance | White crystalline powder |
| HPLC Purity | Cosmetic Grade ≥98.0%; Reference Standard ≥99.5% |
| Water Content (KF) | ≤0.50% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag, small package / 25kg PE lined fiber drum |
| Storage Condition | Hermetic, light-proof cool dry warehouse below 25 °C; avoid high temperature and humid air |
| Transportation Requirement | Bioactive tripeptide solid, light-proof moisture-proof sealed packaging |
| Shelf Life | 24 months under intact nitrogen-filled vacuum packaging |
...
Product
