Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: 1-Propanone, 2-iodo-1-(4-methylphenyl)-
Alias: α-Iodo-4'-methylpropiophenone, 2-Iodo-1-p-tolylpropan-1-one
CAS No.: 236117-38-7
Molecular Formula: C10H11IO
Molecular Weight: 274.10
2. Physical and Chemical Properties
Physical Properties
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Appearance: White to off-white crystalline powder
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Odor: Mild aromatic ketone odor
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Solubility: Insoluble in water; freely soluble in ethanol, methanol, acetone, DMSO, dichloromethane, toluene; slightly soluble in n-hexane
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Predicted Density: 1.584 g/cm3 (20 °C)
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Predicted Boiling Point: 311.1 ± 42.0 °C (760 mmHg)
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Hygroscopicity: Non-hygroscopic under normal ambient humidity
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Optical characteristic: Contains chiral carbon at C2, exists as racemic mixture without optical rotation
Chemical Properties
- Molecular structure: Para-methyl substituted propiophenone with iodine atom on α-carbon adjacent to carbonyl group
- α-Iodine reactivity: Active α-iodo leaving group, prone to SN2 substitution, elimination, cyclization and condensation reactions
- Carbonyl reactivity: Ketone group undergoes imination, reduction, aldol condensation and nucleophilic addition
- Photostability: Sensitive to strong UV light; long-term illumination causes iodine loss and yellow discoloration
- Thermal stability: Stable below 150 °C; high temperature triggers deiodination and decomposition
- Compatibility: Compatible with anhydrous polar organic solvents; incompatible with strong reducing agents, concentrated alkalis, heavy metal salts and strong oxidants
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
- Key α-haloketone building block for synthesis of heterocyclic APIs, anti-inflammatory drugs and central nervous system pharmaceutical molecules
- Precursor for chiral amine, pyrrole, imidazole and indole ring construction via cyclization reaction
2. Organic Synthesis Research Reagent
- Standard substrate for nucleophilic substitution, asymmetric synthesis and organocatalysis laboratory research
- Raw material for fine chemical custom synthesis and fluorescent dye intermediates
3. Chromatography Reference Standard
HPLC/GC calibration sample for qualitative analysis of aromatic α-iodoketone compounds
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 236117-38-7 |
| Molecular Formula | C10H11IO |
| Molecular Weight | 274.10 |
| Appearance | White crystalline powder |
| HPLC Purity | Synthetic Grade ≥98.0%; High Purity Grade ≥99.5% |
| Water Content (KF) | ≤0.10% |
| Residue on Ignition | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic, light-proof cool dry warehouse below 25 °C; isolate reducing substances and strong light |
| Transportation Requirement | Halogenated aromatic ketone solid, dust-proof light-resistant sealed packaging |
| Shelf Life | 24 months under intact nitrogen-filled light-proof vacuum packaging |
Safety Warning
Irritating to skin, eyes and respiratory tract (GHS H315, H319, H335). Iodide decomposition may release irritating iodine vapor under light or heating. All operations must be carried out in ventilated fume hood with dust mask, safety goggles and chemical-resistant gloves. Waste residues are classified as halogenated organic hazardous waste and require professional hazardous waste disposal. Avoid contact with strong reducing agents to prevent toxic iodine release.
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