Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: 2-Cyanopyridine
Alias: Pyridine-2-carbonitrile, 2-Pyridyl cyanide
CAS No.: 100-70-9
Molecular Formula: C6H4N2
Molecular Weight: 104.11
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to pale yellow crystalline solid
- Odor: Mild heterocyclic peculiar odor
- Solubility: Soluble in ethanol, methanol, acetone, dichloromethane, toluene; slightly soluble in cold water, freely soluble in hot water; insoluble in alkane solvents
- Melting Point: 26–28 °C
- Boiling Point: 212–214 °C
- Hygroscopicity: Slightly hygroscopic under high humidity
- Volatility: Slightly volatile at room temperature, vapor has mild irritation
Chemical Properties
- Molecular structure: Pyridine ring with cyano group (-CN) at ortho position; contains aromatic nitrogen heterocycle and nitrile functional group
- Cyano group reactivity: Can undergo hydrolysis to form 2-pyridinecarboxamide / picolinic acid; reduction to 2-aminomethylpyridine; cyclization to construct pyrimidine, imidazole heterocycles
- Pyridine nitrogen characteristic: Weak alkalinity, forms soluble salts with inorganic acids; can coordinate with metal ions
- Thermal stability: Stable below 160 °C; high temperature decomposition releases toxic cyanide fumes
- Photostability: Stable under indoor light; long-term strong UV irradiation slowly turns yellow
- Compatibility: Compatible with anhydrous polar organic solvents; incompatible with strong acid, strong oxidants, strong reducing agents
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
- Key building block for cardiovascular drugs, anti-inflammatory agents, antibacterial and central nervous system APIs
- Precursor for picolinic acid, aminomethylpyridine series intermediates via cyano hydrolysis/reduction
2. Agrochemical Intermediate
Raw material for synthesizing high-efficiency pyridine fungicides, insecticides and herbicide intermediates
3. Metal Chelating & Analytical Reagent
Ligand raw material for metal complex catalysts; HPLC reference standard for pyridine nitrile detection
4. Fine Chemical Material
Synthetic monomer for functional dyes, fluorescent brighteners and pyridine-based polymer additives
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 100-70-9 |
| Molecular Formula | C6H4N2 |
| Molecular Weight | 104.11 |
| Appearance | White crystalline solid |
| HPLC Purity | Synthetic Grade ≥98.0%; Reference Standard ≥99.5% |
| Water Content (KF) | ≤0.10% |
| Residue on Ignition | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic cool dry warehouse below 25 °C; isolate acid, oxidants and humid air |
| Transportation Requirement | Nitrile heterocyclic toxic solid, dust-proof sealed packaging |
| Shelf Life | 24 months under intact nitrogen-filled sealed packaging |
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