Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: N-Ethylformamide
Alias: N-Ethylmethanamide
CAS No.: 627-45-2
Molecular Formula: C3H7NO
Molecular Weight: 73.09
2. Physical and Chemical Properties
Physical Properties
- Appearance: Colorless transparent viscous liquid
- Odor: Mild faint amide characteristic odor
- Solubility: Miscible freely with water, ethanol, methanol, acetone, dichloromethane; slightly soluble in aliphatic hydrocarbons
- Melting Point: ?60 °C
- Boiling Point: 202–204 °C
- Density: 0.950 g/cm3 (20 °C)
- Hygroscopicity: Strongly hygroscopic, rapidly absorbs moisture from air
Chemical Properties
- Molecular structure: Formamide with ethyl group substituted on nitrogen atom, contains amide functional group -CONH-
- Hydrolysis characteristic: Slow hydrolysis under neutral conditions; rapid hydrolysis under strong acid/strong alkali heating to generate formic acid and ethylamine
- Polar aprotic solvent property: High polarity, good dissolving capacity for inorganic salts, polymers, pharmaceutical intermediates
- Thermal stability: Stable below 140 °C; prolonged high temperature decomposes to release ethylamine and formate derivatives
- Photostability: Stable under indoor light; long-term UV irradiation slightly yellows
- Compatibility: Compatible with most polar organic solvents; incompatible with strong acids, strong bases, strong dehydrating agents, strong oxidants
3. Main Application Fields
1. High-Polar Industrial Solvent (Core Application)
- Special solvent for polymer spinning, resin coating, lithium battery slurry auxiliary solvent
- Dissolving medium for metal salt catalytic reactions, homogeneous synthesis reactions
2. Pharmaceutical Synthetic Reaction Medium
High-boiling polar solvent for heterocyclic API synthesis, improves reaction conversion rate for formylation, cyclization processes
3. Organic Formylation Reagent
Mild formyl donor for selective N-formylation of amine substrates under mild conditions
4. Laboratory Special Chromatographic Eluent
High-polarity mobile phase additive for reversed-phase HPLC separation of polar peptide and amino acid samples
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 627-45-2 |
| Molecular Formula | C3H7NO |
| Molecular Weight | 73.09 |
| Appearance | Colorless clear liquid |
| GC Purity | Industrial Grade ≥99.0%; Synthetic Reagent Grade ≥99.5% |
| Water Content (KF) | ≤0.15% |
| Free Acid (Formic acid) | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 200L sealed steel drum / 25L PE plastic drum |
| Storage Condition | Hermetic cool dry ventilated warehouse below 25 °C; isolate moisture, acid and alkali raw materials |
| Transportation Requirement | Non-flammable toxic amide liquid, leak-proof sealed packaging |
| Shelf Life | 24 months under intact sealed packaging |
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