Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: 2-Oxo-4-phenylpyrrolidine-1-acetic acid hydrazide
Alias: Phenylpiracetam hydrazide, Fonturacetam hydrazide, Piracetam Impurity 7
CAS No.: 77472-71-0
Molecular Formula: C12H15N3O2
Molecular Weight: 233.27
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Faint mild odor characteristic of hydrazides
- Solubility: Soluble in water and methanol; slightly soluble in hot ethanol; practically insoluble in ether, n-hexane and benzene
- Melting Point: 154–155 °C
- Density: 1.243 g/cm3 (20 °C)
- Boiling Point: 529.4 ± 50.0 °C (760 mmHg)
- Hygroscopicity: Slightly hygroscopic under high humidity conditions
Chemical Properties
- Molecular Structure: A racetam pyrrolidone derivative, consisting of a 2-pyrrolidinone ring with a phenyl substituent at the 4-position and a terminal acyl hydrazide group (-CONHNH?)
- Hydrazide Reactivity: The terminal -NHNH? group undergoes condensation, cyclization, acylation and diazotization reactions to construct heterocyclic pharmaceutical skeletons
- Lactam Stability: The pyrrolidone ring remains stable under neutral and weakly acidic environments, but hydrolyzes upon heating with strong acids or strong alkalis
- Antioxidant Activity: The hydrazide moiety exhibits weak reducing capacity with free radical scavenging and potential neuroprotective effects
- Photostability: Slightly sensitive to intense UV light; prolonged illumination causes pale yellow discoloration
- Compatibility: Compatible with polar protic solvents; incompatible with strong oxidants, aldehydes and heavy metal salts
3. Main Application Fields
1. Pharmaceutical Intermediates (Core Application)
- Official reference impurity standard of Phenylpiracetam (Piracetam Impurity 7) for pharmaceutical quality control and testing
- Synthetic precursor for novel nootropic and neuroprotective APIs; the hydrazide group serves as a critical reactive site for further derivatization
- Raw material for research on anticonvulsant and cerebral metabolism-improving drugs
2. Biochemical Laboratory Reagents
- Substrate for nootropic research in cell experiments targeting dopamine and acetylcholine receptors
- HPLC reference standard for quantitative detection of racetam cognitive-enhancing drug residues
3. Raw Material for Cognitive Function Research
Experimental compound for neuroscience laboratory studies on memory improvement, anti-fatigue and neuroprotective mechanisms
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 77472-71-0 |
| Molecular Formula | C12H15N3O2 |
| Molecular Weight | 233.27 |
| Appearance | White crystalline powder |
| HPLC Purity | Reference Standard Grade ≥99.5%; Synthetic Grade ≥98.0% |
| Melting Point | 154–155 °C |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-sealed amber aluminum foil vacuum bags / 25kg PE-lined fiber drums |
| Storage Condition | Hermetically sealed, cool and dry warehouse below 25 °C; segregated from oxidants and humid air |
| Transportation Requirement | Hydrazide-based pharmaceutical intermediate solid, dust-proof and light-resistant sealed packaging |
| Shelf Life | 24 months under intact nitrogen-filled light-proof vacuum packaging |
...
Product
