Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Bimatoprost
Alias: (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
CAS No.: 155206-00-1
Molecular Formula: C25H34O5N
Molecular Weight: 428.54
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Soluble in ethanol, methanol, DMSO, acetonitrile; slightly soluble in water; insoluble in alkane solvents
- Melting Point: 66–68 °C
- Specific Rotation: [α]D2? ?32° ~ ?38° (methanol solution)
- Hygroscopicity: Slightly hygroscopic under high humidity
Chemical Properties
- Molecular Structure: Synthetic prostaglandin F2α amide analog, contains cyclopentane ring, three hydroxyl groups, two carbon-carbon double bonds and ethyl amide functional group with multiple chiral centers
- Hydroxyl Activity: Hydroxyl groups can undergo esterification, acylation and oxidation reactions; easily oxidized under strong light or oxidizing conditions
- Double Bond Characteristic: Unsaturated carbon-carbon bonds are prone to cis-trans isomerization and oxidative degradation
- pH Stability: Stable under neutral and weak acidic conditions; rapidly degraded under strong alkaline or high-temperature environment
- Photostability: Highly sensitive to UV light; long-term illumination produces related degradation impurities and reduces biological activity
- Compatibility: Compatible with polar organic solvents and ophthalmic formulation excipients; incompatible with strong oxidants, concentrated alkalis and heavy metal ions
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Active ingredient for ophthalmic eye drops to reduce intraocular pressure, clinically used for treatment of open-angle glaucoma and ocular hypertension
- Medical cosmetic raw material for eyelash growth serums, effectively prolongs eyelash growth cycle and increases lash thickness and density
2. Pharmacological Research Reagent
- Reference standard for HPLC detection of prostaglandin drugs in pharmaceutical preparations
- Cell experiment tool for prostaglandin FP receptor signal pathway research
3. Drug Impurity Standard
Calibration substance for quality control testing of bimatoprost ophthalmic formulations
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 155206-00-1 |
| Molecular Formula | C25H34NO5 |
| Molecular Weight | 428.54 |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Single Unknown Impurity | ≤0.10% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetically sealed, cool dark warehouse at 2–8 °C; isolate oxidants and strong light |
| Transportation Requirement | Bioactive prostaglandin API, cold-chain light-proof sealed packaging |
| Shelf Life | 24 months under intact low-temperature nitrogen-sealed vacuum packaging |
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