Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Di-tert-butyl dicarbonate
Abbreviation: Boc?O
Alias: Bis(1,1-dimethylethyl) dicarbonate, tert-Butyl pyrocarbonate
CAS No.: 24424-99-5
Molecular Formula: C10H18O5
Molecular Weight: 218.25
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline solid
- Odor: Mild characteristic carbonate odor
- Solubility: Insoluble in water; freely soluble in dichloromethane, tetrahydrofuran, toluene, ethyl acetate; slightly soluble in n-hexane
- Melting Point: 22–24 °C
- Boiling Point: Decomposes above 80 °C
- Hygroscopicity: Slightly hygroscopic, slowly hydrolyzed by moisture in air
- Volatility: Slightly volatile at room temperature
Chemical Properties
- Molecular Structure: Dicarbonate with two tert-butyl ester groups, widely used Boc protecting reagent for amines
- Protecting Group Reaction: Selectively reacts with primary and secondary amines under mild neutral/weak alkaline conditions to form Boc-amino derivatives; Boc group can be cleaved by trifluoroacetic acid or HCl/dioxane
- Hydrolysis Stability: Stable under anhydrous environment; rapidly hydrolyzed in water, alcohol or humid air to generate tert-butanol and carbon dioxide
- Thermal Sensitivity: Decomposes obviously over 60 °C; high temperature releases CO? and isobutylene, prone to violent decomposition under excessive heating
- Photostability: Sensitive to strong light; long-term illumination accelerates decomposition
- Compatibility: Compatible with anhydrous aprotic solvents; incompatible with water, alcohols, strong acids, strong nucleophiles, oxidants
3. Main Application Fields
1. Pharmaceutical Synthetic Reagent (Core Application)
- Amine protecting reagent for peptide synthesis, amino acid modification and heterocyclic API manufacturing
- Key raw material for producing Boc-protected intermediates of cardiovascular, anti-tumor and central nervous system drugs
2. Biochemical Research Reagent
- Blocking reagent for amino groups in protein, enzyme and polypeptide labeling experiments
- Standard reagent for solid-phase peptide synthesis (SPPS)
3. Fine Chemical Intermediate
Synthetic building block for chiral amines, amine catalysts and agrochemical intermediates
4. Laboratory Analytical Standard
Reference substance for HPLC/GC detection of carbamate protecting group derivatives
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 24424-99-5 |
| Molecular Formula | C10H18O5 |
| Molecular Weight | 218.25 |
| Appearance | White crystalline powder |
| HPLC Purity | Synthetic Grade ≥98.0%; Peptide Synthesis Grade ≥99.0% |
| Melting Point | 22–24 °C |
| Water Content (KF) | ≤0.10% |
| Residue on Ignition | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic, light-proof cold warehouse at 2–8 °C; isolate moisture, alcohols and acidic materials |
| Transportation Requirement | Moisture-sensitive carbonate solid, dust-proof low-temperature sealed packaging |
| Shelf Life | 12 months under intact nitrogen-filled cold vacuum packaging |
Safety Warning
Irritating solid, dust inhalation, skin and eye contact cause severe irritation. Thermal decomposition releases flammable isobutylene gas, risk of explosion under sealed high temperature. All operations must be conducted in anhydrous ventilated fume hood with chemical-resistant gloves, dust mask and safety goggles. Strictly avoid contact with water, alcohol and strong acid. Waste residues and waste liquid are classified as organic hazardous waste and require professional centralized disposal. Must be stored refrigerated and sealed away from light to prevent hydrolysis and thermal decomposition.
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