Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: ε-Chlorocapronitrile
Alias: 6-Chlorohexanenitrile, 6-Chloro-n-hexyl cyanide
CAS No.: 6628-78-0
Molecular Formula: C6H10ClN
Molecular Weight: 131.60
2. Physical and Chemical Properties
Physical Properties
- Appearance: Colorless transparent oily liquid
- Odor: Pungent nitrile characteristic odor
- Solubility: Insoluble in water; miscible with ethanol, methanol, dichloromethane, toluene, ethyl acetate and other organic solvents
- Boiling Point: 108–110 °C (12 mmHg)
- Density: 1.036 g/cm3 (20 °C)
- Refractive Index: 1.459–1.463 (20 °C)
- Hygroscopicity: Slightly hygroscopic
Chemical Properties
- Molecular Structure: Straight-chain aliphatic nitrile with chlorine atom at the terminal 6-position, containing cyano group (-CN) and chloro substituent (-Cl)
- Cyano reactivity: Cyano group can undergo hydrolysis, reduction, cyclization to generate carboxylic acids, amines and nitrogen heterocyclic intermediates
- Alkyl chloride reactivity: Terminal Cl is active leaving group, easy to carry out SN2 substitution with amines, alcohols, thiols
- Thermal stability: Stable under normal temperature; high temperature decomposition releases toxic cyanide and hydrogen chloride gas
- Photostability: Slightly sensitive to strong light; long-term illumination turns light yellow
- Compatibility: Compatible with anhydrous organic solvents; incompatible with strong alkali, strong reducing agents, strong oxidants, ammonia water
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
- Key linear aliphatic building block for anti-depressant, anti-hypertensive and amino acid derivative APIs
- Precursor for synthesizing six-membered aliphatic amine, lactam and heterocyclic pharmaceutical intermediates via substitution and cyclization
2. Fine Chemical & Agrochemical Raw Material
Synthetic intermediate for high-efficiency herbicides, insecticides and functional cationic surfactants
3. Organic Synthesis Reagent
Substrate for laboratory nucleophilic substitution, aliphatic chain extension and heterocyclic construction reactions
4. Chromatography Reference Standard
GC calibration standard for aliphatic chloro-nitrile impurity detection
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 6628-78-0 |
| Molecular Formula | C6H10ClN |
| Molecular Weight | 131.60 |
| Appearance | Colorless clear oily liquid |
| GC Purity | Synthetic Grade ≥98.0%; High Purity Grade ≥99.0% |
| Water Content (KF) | ≤0.10% |
| Free Chloride Ion | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 25L / 200L sealed amber steel drum |
| Storage Condition | Hermetic cool dark warehouse below 25 °C; segregated from alkaline and oxidizing substances |
| Transportation Requirement | Toxic halogenated nitrile liquid, leak-proof light-resistant sealed packaging |
| Shelf Life | 24 months under intact sealed packaging |
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