Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Finasteride
Alias: N-(1,1-dimethylethyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide
CAS No.: 98319-26-7
Molecular Formula: C23H36N2O2
Letter-number format molecular formula: C23H36N2O2
Molecular Weight: 372.55
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Insoluble in water; soluble in ethanol, methanol, chloroform, dichloromethane; slightly soluble in propylene glycol
- Melting Point: 252–254 °C
- Hygroscopicity: Non-hygroscopic under normal ambient humidity
- Crystal property: Orthorhombic crystal after recrystallization
Chemical Properties
- Molecular Structure: Steroid 5α-reductase inhibitor, four-ring steroid skeleton containing amide group and cyclic imide nitrogen atom
- Functional group reactivity: Tertiary amide group is stable under neutral condition; hydrolyzed under strong acid or strong alkali heating to generate carboxylic acid and tert-butylamine
- Stereochemical stability: Single chiral configuration remains stable at room temperature; high temperature may trigger partial isomerization
- Thermal stability: Stable below 180 °C; significant decomposition above 240 °C
- Photostability: Slightly sensitive to strong UV light; long-term light exposure turns faint yellow
- Compatibility: Compatible with neutral pharmaceutical excipients, lipid carriers; incompatible with strong oxidants, concentrated strong alkalis and heavy metal ions
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Oral tablet active ingredient for treating benign prostatic hyperplasia (BPH), relieving frequent micturition and dysuria symptoms
- Clinical raw material for androgenetic alopecia treatment, inhibits dihydrotestosterone generation to slow hair loss and promote hair regrowth
2. Pharmacological Research Reagent
- Selective 5α-reductase inhibitor standard for cell and animal model experiments
- HPLC reference standard for quality control of finasteride pharmaceutical preparations
3. Steroid Synthetic Intermediate
Chiral steroid raw material for developing anti-androgen related derivative drugs
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 98319-26-7 |
| Molecular Formula | C23H36N2O2 |
| Appearance | White crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Melting Point | 252–254 °C |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic cool dark warehouse below 25 °C; segregated from oxidants and alkaline materials |
| Transportation Requirement | Low-toxic steroid API solid, dust-proof light-resistant sealed packaging |
| Shelf Life | 36 months under intact nitrogen-sealed vacuum packaging |
Safety Warning
Hormone-related active pharmaceutical compound. Dust inhalation irritates eyes and respiratory tract; women of childbearing age must avoid contact (may cause fetal developmental abnormalities). Wear dust mask, chemical-resistant gloves and safety goggles during all operations. Avoid long-term exposure to high temperature and strong light to prevent degradation impurities. Waste residues and waste liquid belong to pharmaceutical organic hazardous waste and require professional centralized hazardous waste disposal.
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