Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Guanidine hydrochloride
Alias: Guanidinium chloride
CAS No.: 50-01-1
Molecular Formula: C1H6N3Cl1
Molecular Weight: 95.53
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water, methanol, ethanol; slightly soluble in acetone; insoluble in ether, benzene
- Melting Point: Decomposes at 181–183 °C
- Hygroscopicity: Moderately hygroscopic in humid air
- Aqueous property: Strongly acidic aqueous solution
Chemical Properties
- Molecular Structure: Ionic compound composed of guanidinium cation and chloride anion
- Strong denaturation: High concentration breaks hydrogen bonds of protein, widely used for protein denaturation and solubilization
- Alkaline hydrolysis: Reacts with strong alkali to release free guanidine
- Salt formation: Can form composite salts with various inorganic acids and organic acids
- Thermal stability: Stable at room temperature; decomposes above melting point to produce ammonia and hydrogen chloride gas
- Photostability: Stable under indoor light; no obvious degradation
- Compatibility: Compatible with water-soluble biochemical reagents; incompatible with strong alkali, oxidants, heavy metal salts
3. Main Application Fields
1. Biochemical Research Reagent (Core Application)
- Protein denaturant for protein purification, inclusion body solubilization
- Raw material for nucleic acid extraction kits to remove protein impurities from DNA/RNA samples
2. Pharmaceutical Synthetic Intermediate
- Key raw material for synthesizing sulfonamides, anti-diabetic drugs and anti-viral APIs
- Catalyst for cyclization reaction in steroid and heterocyclic compound synthesis
3. Cosmetic & Daily Chemical Auxiliary
Disinfection auxiliary and hair perming auxiliary raw material
4. Industrial Chemical Additive
Raw material for organic synthesis flocculant, resin curing accelerator
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 50-01-1 |
| Molecular Formula | C1H6N3Cl1 |
| Appearance | White crystalline powder |
| HPLC Assay | Biochemical Grade ≥99.0%; Pharma Grade ≥99.5% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled PE vacuum bag / 25kg PE lined fiber drum |
| Storage Condition | Hermetic cool dry warehouse below 25 °C; isolated from alkaline substances |
| Transportation Requirement | Non-dangerous goods, moisture-proof dust-proof sealed packaging |
| Shelf Life | 36 months under intact sealed packaging |
Safety Warning
Irritating crystalline solid. Dust severely irritates eyes, skin and respiratory tract; high-concentration solution causes skin corrosion. Wear dust mask, acid-resistant gloves and safety goggles during operation. Avoid contact with strong alkali to release irritant guanidine gas. Waste liquid needs neutralization treatment before discharge; residues belong to nitrogen-containing organic hazardous waste requiring professional disposal.
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