Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Common Name: Gatifloxacin
Alias: AM-1155, Tequin
CAS No.: 112811-59-3
Letter-number format molecular formula: C19H22F1N3O4
Molecular Weight: 375.39
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to pale yellow crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in water; soluble in dilute acid, DMSO, DMF; slightly soluble in methanol; insoluble in ether, hexane
- Melting Point: 162 °C
- Hygroscopicity: Slightly hygroscopic under high humidity
- Optical property: Contains chiral carbon on 3-methylpiperazine ring, exists as racemic mixture
Chemical Properties
- Molecular Structure: Fourth-generation 8-methoxy fluoroquinolone, quinoline parent ring with cyclopropyl, fluorine, methoxy, 3-methylpiperazinyl, ketone and carboxyl functional groups
- Antibacterial mechanism: Inhibits bacterial DNA gyrase and topoisomerase IV, blocks DNA replication and transcription
- Acid-base reactivity: Carboxyl group reacts with alkalis to form soluble gatifloxacin salt; stable in weak acid/neutral medium, carboxyl esterified under strong acid heating
- Phototoxicity: Sensitive to strong UV light; long-term illumination generates photodegradation impurities with phototoxic risk
- Thermal stability: Stable below 120 °C; obvious pyrolysis above 250 °C
- Compatibility: Compatible with aqueous pharmaceutical excipients; incompatible with strong oxidants, ferric ions, aluminum salts, cationic surfactants
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Oral tablet, injection raw material for systemic antibacterial therapy; treats respiratory tract, urinary tract, genital bacterial infections
- Ophthalmic API for eye drops, for clinical treatment of bacterial conjunctivitis
2. Biochemical Research Reagent
- Broad-spectrum antibacterial standard for bacteriology drug susceptibility tests
- HPLC reference standard for quality control of gatifloxacin pharmaceutical preparations
3. Fine Chemical Synthetic Intermediate
Raw material for preparing gatifloxacin mesylate, gatifloxacin hydrochloride soluble salt derivatives
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 112811-59-3 |
| Molecular Formula | C19H22F1N3O4 |
| Appearance | White crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Melting Point | 162 °C |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic cool dark warehouse below 25 °C; strictly isolated from light, oxidants and metal salts |
| Transportation Requirement | Fluoroquinolone antibiotic solid, dust-proof light-resistant sealed packaging |
| Shelf Life | 36 months under intact nitrogen-sealed vacuum packaging |
Safety Warning
Irritating antibacterial API. Dust inhalation irritates eyes, nasal mucosa and respiratory tract; long-term skin contact may cause photosensitive dermatitis. Pregnant women, adolescents under 18 avoid exposure. Wear dust mask, chemical-resistant gloves and full-face goggles during all operations. Avoid outdoor light exposure during production and storage to prevent photodegradation. Waste residues and waste liquid belong to pharmaceutical organic hazardous waste and require professional centralized harmless disposal.
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