Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Progesterone
Alias: Pregn-4-ene-3,20-dione
CAS No.: 57-83-0
Molecular Formula: C21H30O2
Letter-number format molecular formula: C21H30O2
Molecular Weight: 314.46
2. Physical and Chemical Properties
Physical Properties
- Appearance: White or off-white crystalline powder
- Odor: Odorless
- Solubility: Insoluble in water; soluble in ethanol, methanol, chloroform, acetone, ether; slightly soluble in vegetable oil
- Melting Point: 128–132 °C
- Hygroscopicity: Non-hygroscopic under normal humidity
- Optical property: Optically active steroid compound
Chemical Properties
- Molecular Structure: Natural pregnane steroid, four-ring steroid skeleton, contains two ketone carbonyl groups and C4-C5 carbon-carbon double bond
- Functional group reactivity: Conjugated ketone structure can undergo addition, reduction, condensation reactions; can form ester derivatives after structural modification
- Stereostability: Natural configuration stable at room temperature; high temperature may trigger double bond isomerization to produce impurities
- Thermal stability: Stable below 110 °C; obvious thermal decomposition above 230 °C
- Photostability: Sensitive to ultraviolet light; long-term light exposure turns pale yellow and generates oxidation impurities
- Compatibility: Compatible with lipid pharmaceutical excipients; incompatible with strong oxidants, concentrated strong acid, heavy metal ions
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Oral/Injectable hormone raw material for gynecology; treats luteal insufficiency, threatened abortion, irregular menstruation
- Key intermediate for synthesizing contraceptives, corticosteroids and other steroid drugs
2. Biochemical Research Reagent
HPLC reference standard for hormone detection; research tool for reproductive endocrinology cell and animal experiments
3. Cosmetic Functional Additive
Anti-aging skin care raw material for high-end topical formulations to regulate skin cell proliferation
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 57-83-0 |
| Molecular Formula | C21H30O2 |
| Appearance | White crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Melting Point | 128–132 °C |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic cool dark warehouse below 25 °C; segregated from light, oxidants and acidic substances |
| Transportation Requirement | Steroid hormone solid, dust-proof light-resistant sealed packaging |
| Shelf Life | 36 months under intact nitrogen-sealed vacuum packaging |
Safety Warning
Hormonal active steroid substance. Dust inhalation irritates eyes and respiratory tract; long-term skin contact may disrupt human endocrine balance. Pregnant women, minors must avoid direct contact. Wear dust mask, chemical-resistant gloves and full-face goggles during all operations. Strictly avoid light exposure during storage and processing to prevent degradation. Waste residues and waste liquid belong to pharmaceutical organic hazardous waste and require professional centralized harmless disposal.
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