Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Orlistat
Alias: Tetrahydrolipstatin
CAS No.: 96829-58-2
Molecular Formula: C29H53NO5
Letter-number format molecular formula: C29H53N1O5
Molecular Weight: 495.73
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Slight characteristic fatty odor
- Solubility: Insoluble in water; soluble in chloroform, dichloromethane, ethanol, isopropanol; slightly soluble in vegetable oil
- Melting Point: 44–46 °C
- Hygroscopicity: Non-hygroscopic under normal humidity
- Optical property: Optically active chiral lipase inhibitor
Chemical Properties
- Molecular Structure: Lipstatin derivative, long-chain aliphatic skeleton containing β-lactone ring, amide group and alkyl side chain
- Core inhibitory mechanism: β-lactone ring binds covalently with gastrointestinal lipase, blocks fat decomposition and absorption
- Hydrolysis characteristic: Lactone ring easily hydrolyzes under strong acid, strong alkali or high temperature to lose pharmacological activity
- Thermal stability: Stable below 40 °C; lactone ring cleavage occurs above 60 °C to produce inactive degradation impurities
- Photostability: Sensitive to UV light; long-term light exposure causes yellowing and loss of activity
- Compatibility: Compatible with oily pharmaceutical excipients; incompatible with strong oxidants, strong acid/alkali, heavy metal ions
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Oral weight-loss drug raw material, clinically used for obesity and overweight population weight control
- Reduces intestinal fat absorption, lowers blood lipid auxiliary treatment
2. Biochemical Research Reagent
Specific lipase inhibitor for fat metabolism research; HPLC reference standard for orlistat formulation quality inspection
3. Synthetic Intermediate
Raw material for sustained-release orlistat derivative preparations
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 96829-58-2 |
| Molecular Formula | C29H53N1O5 |
| Appearance | White crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic cool dark warehouse below 25 °C; avoid high temperature, light and acid/alkali materials |
| Transportation Requirement | Lipase inhibitor pharmaceutical solid, light-proof sealed packaging |
| Shelf Life | 24 months under nitrogen-sealed vacuum packaging |
Safety Warning
Medicinal active ingredient. Dust splashing irritates eyes and respiratory tract; accidental oral overdose may cause oily stool, abdominal distension, diarrhea and other gastrointestinal adverse reactions. Pregnant women, lactating women and malabsorption patients are prohibited from contact. Wear dust mask, chemical-resistant gloves and protective goggles during operation. Strictly avoid high temperature and light during storage to prevent lactone ring hydrolysis deactivation. Waste residues and waste liquid belong to pharmaceutical organic hazardous waste and need professional centralized disposal.
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