Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Atractyloside Potassium Salt
1. Basic Information
Name: Atractyloside Potassium Salt
Alias: Dipotassium Atractyloside
CAS No.: 102130-43-8
Molecular Formula: C30H44K2O16S2
Molecular Weight: 802.99
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale beige to light brown crystalline powder
- Odor: Odorless diterpenoid glycoside powder
- Solubility: Soluble in H2O and DMSO; slightly soluble in CH3OH; insoluble in C2H5OH, alkanes and CHCl3
- Melting Point: 234–238 °C (decomposition)
- Hygroscopicity: Highly hygroscopic, prone to caking under humid conditions
- Aqueous Characteristic: Weakly acidic transparent aqueous solution
Chemical Properties
- Molecular Structure: Natural tetracyclic diterpene glycoside disulfate dipotassium salt, containing glucose disulfate moiety, isovalerate ester group and two K1+ counterions
- Biological Activity: Specific inhibitor of mitochondrial ADP/ATP translocase (ANT), inhibits mitochondrial oxidative phosphorylation
- Hydrolysis Behavior: Ester bonds and sulfate groups hydrolyze under strong acid or alkaline heating, resulting in loss of biological activity
- Oxidation Stability: Susceptible to oxidation under UV light and air exposure, turning dark brown over time
- Thermal Stability: Stable below 40 °C; glycosidic bonds break and decompose at elevated temperatures
- Compatibility: Incompatible with strong oxidants, heavy metal ions and concentrated strong alkalis
3. Main Application Fields
1. Biochemical Research Reagent (Core Application)
- Mitochondrial energy metabolism research tool; specific ANT inhibitor for apoptosis and autophagy mechanism studies
- Mitochondrial ion channel blocker for cardiovascular cell model assays
2. Pharmacology & Anti-Tumor Research Reagent
- In vitro screening tool for pathways related to non-small cell lung cancer and hepatic steatosis
- Reference standard for quantifying atractyloside content in toxic traditional herbal materials
3. Toxicology Reference Substance
Nephrotoxicity inducer for establishing in vitro and in vivo renal injury models
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 102130-43-8 |
| Molecular Formula | C30H44K2O16S2 |
| Appearance | Pale beige crystalline powder |
| HPLC Purity | Biochemical Grade ≥98.0%; Reference Standard ≥99.5% |
| Water Content (KF) | ≤0.50% |
| Residue on Ignition | ≤0.20% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb1) | ≤10 ppm |
| Packaging | Nitrogen-purged amber aluminum foil vacuum bag / low-temperature reagent fiber drum |
| Storage Condition | Hermetically sealed at -20 °C in dark environment; strictly moisture-proof, light-proof and isolated from oxidants |
| Transportation Requirement | Toxic biochemical reagent, cold chain fully sealed packaging |
| Shelf Life | 36 months under nitrogen-sealed vacuum cryogenic storage |
Safety Warning
Highly nephrotoxic biochemical reagent. Dust severely irritates eyes, respiratory tract and skin; inhalation or percutaneous absorption causes mitochondrial damage and renal toxicity. Handle in well-ventilated fume hood with dust mask, acid-resistant gloves and full-face sealed goggles. Store hermetically at low temperature to avoid moisture absorption and oxidative degradation. Waste liquid requires neutralization and detoxification treatment; solid waste is classified as toxic biological hazardous waste and must be disposed of by professional hazardous waste institutions.
...
Product
