Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Isovanillin
1. Basic Information
Name: Isovanillin
Alias: 3-Hydroxy-4-methoxybenzaldehyde
CAS No.: 621-59-0
Molecular Formula: C8H8O3
Molecular Weight: 152.15
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale yellow crystalline powder
- Odor: Mild aromatic odor
- Solubility: Soluble in CH3OH, C2H5OH, acetone, CHCl3; slightly soluble in hot H2O; insoluble in aliphatic hydrocarbons
- Melting Point: 113–115 °C
- Hygroscopicity: Slightly hygroscopic under high humidity
- Aqueous Characteristic: Weakly acidic aqueous solution
Chemical Properties
- Molecular Structure: Aromatic benzaldehyde with 3-hydroxy and 4-methoxy substituents on benzene ring
- Aldehyde Reactivity: Capable of condensation, reduction, oxidation and Schiff base formation reactions
- Phenolic Hydroxyl Feature: Reacts with alkalis to form soluble phenates; easily oxidized by air and UV light to dark quinone impurities
- Thermal Stability: Stable below 70 °C; prolonged heating above melting point accelerates oxidative discoloration
- Photostability: Sensitive to ultraviolet light; long-term light exposure turns dark brown
- Compatibility: Incompatible with strong oxidants, heavy metal salts and concentrated alkaline solutions
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Raw material for synthesizing antioxidants, anti-inflammatory agents and heterocyclic pharmaceutical compounds
2. Dye & Fluorescent Pigment Intermediate
Precursor for mordant dyes, fluorescent colorants and color-developing reagents
3. Biochemical Analytical Reagent
Chromogenic reagent for qualitative detection of metal ions; HPLC reference standard
4. Organic Synthesis Building Block
Raw material for preparing Schiff base ligands and polymer modifiers
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 621-59-0 |
| Molecular Formula | C8H8O3 |
| Appearance | Pale yellow crystalline powder |
| HPLC Purity | Synthetic Grade ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb1) | ≤10 ppm |
| Packaging | Amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetically sealed in cool dark warehouse below 25 °C; isolate from air, light and oxidants |
| Transportation Requirement | Oxidation-prone phenolic solid, light-proof fully sealed packaging |
| Shelf Life | 24 months under complete sealed packaging |
Safety Warning
Irritant phenolic compound. Dust irritates eyes, nasal mucosa and skin; long-term skin contact may induce allergic dermatitis. Operate in ventilated environment with dust mask, chemical-resistant gloves and protective goggles. Avoid prolonged exposure to air and light to prevent oxidative darkening. Waste liquid needs neutralization before discharge; solid waste belongs to organic hazardous waste and requires professional centralized disposal.
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