Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Mercaptothiazole
1. Basic Information
Name: 2-Mercaptothiazole
CAS No.: 82358-09-6
Molecular Formula: C3H3NS2
Molecular Weight: 117.19
Category: Sulfur-containing nitrogen heterocyclic fine chemical intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale yellow crystalline powder
- Odor: Strong pungent sulfurous heterocyclic odor
- Solubility: Soluble in methanol, ethanol, acetone, DMSO and chloroform; slightly soluble in hot water; insoluble in aliphatic hydrocarbon solvents
- Melting Range: 68–72 °C
- Hygroscopy: Slightly hygroscopic under high humidity conditions
- Aqueous Property: Weakly acidic aqueous solution due to active thiol group
Chemical Properties
- Molecular Structure: Five-membered thiazole ring with a mercapto (-SH) substituent at position 2
- Thiol Reactivity: Active sulfhydryl group undergoes alkylation, esterification, metal chelation and oxidation disulfide formation reactions
- Heterocycle Activity: Thiazole ring supports electrophilic substitution and condensation reactions for drug skeleton construction
- Thermal Stability: Stable below 60 °C; prolonged heating above melting point triggers oxidation and sulfur release
- Photostability: Highly sensitive to UV light; long-term illumination accelerates oxidation and darkens the solid
- Compatibility: Miscible with most polar organic solvents; incompatible with strong oxidants, heavy metal ions and concentrated alkaline reagents
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key building block for synthesizing antibacterial, antifungal and anti-inflammatory APIs containing thiazole ring; widely used for thiol derivatization and heterocyclic coupling reactions
2. Metal Surface Treatment Additive
Corrosion inhibitor and metal chelating agent for electroplating, metal pickling and wastewater heavy metal removal
3. Rubber & Polymer Vulcanization Auxiliary
Minor sulfur-containing vulcanization accelerator for special rubber and resin materials
4. HPLC Reference Standard
Reference substance for quantitative detection of mercaptothiazole intermediates in chemical production
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 82358-09-6 |
| Molecular Formula | C3H3NS2 |
| Appearance | Uniform pale yellow crystalline powder without foreign impurities |
| HPLC Purity | Synthetic Intermediate Grade ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Melting Range | 68–72 °C |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-purged amber vacuum aluminum foil bags / PE-lined fiber drums |
| Storage Condition | Hermetically sealed cool dark warehouse below 25 °C; strictly isolated from light, oxidants, moisture and alkaline chemicals |
| Transportation Requirement | Odorous light-sensitive sulfur heterocyclic solid, fully sealed light-proof airtight packaging |
| Shelf Life | 24 months under nitrogen-filled vacuum sealed storage |
Safety Warning
Irritant sulfur-containing heterocyclic crystalline powder. Dust and volatile vapor cause severe irritation to eyes, respiratory tract and skin; prolonged contact may induce skin allergy and mucosal inflammation. All operations must be carried out inside ventilated chemical fume hoods with dust respirators, chemical-resistant gloves and full-face safety goggles. Airtight dark storage is mandatory to prevent thiol oxidation and odor leakage. Waste liquid requires organic solvent recovery and neutralization treatment; solid waste is classified as organic hazardous waste and must be disposed by licensed professional hazardous waste treatment facilities.
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