Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Phenacetin
1. Basic Information
Name: Phenacetin
Alias: Acetophenetidin, p-Acetophenetidine
CAS No.: 62-44-2
Molecular Formula: C10H13NO2
Molecular Weight: 179.22
Category: Aromatic amide pharmaceutical raw material and analytical standard
2. Physical and Chemical Properties
Physical Properties
- Appearance: White lustrous crystalline scale or fine crystalline powder
- Odor: Odorless, slightly bitter taste
- Solubility: Slightly soluble in cold water, soluble in hot water, ethanol, acetone, chloroform; slightly soluble in ether
- Melting Range: 134–136 °C
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Aqueous Property: Neutral aqueous solution, stable in neutral and weak acidic water environment
Chemical Properties
- Molecular Structure: Para-ethoxyacetanilide, benzene ring connected with ethoxy group and acetamide group at para positions
- Amide Hydrolysis: Under strong acid or alkaline heating, acetamide group hydrolyzes to generate p-phenetidine and acetic acid
- Redox Stability: Stable under normal light and temperature; easy to oxidize and turn yellow under long-term strong light and high temperature
- Derivatization Reaction: Amino group after hydrolysis can undergo diazotization, coupling and other reactions for dye synthesis
- Photostability: Moderately sensitive to ultraviolet light; long-term illumination leads to yellow discoloration
- Compatibility: Compatible with most neutral pharmaceutical excipients; incompatible with strong oxidants, concentrated strong acid and strong alkali
3. Main Application Fields
1. Laboratory Reference Standard (Core Application)
HPLC reference standard for drug impurity testing, forensic toxicology detection and pharmaceutical quality control
2. Organic Synthetic Intermediate
Raw material for synthesizing analgesic, antipyretic and azo dye compounds
3. Analytical Chemical Reagent
Organic standard reagent for laboratory chromatographic and spectroscopic research
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 62-44-2 |
| Molecular Formula | C10H13NO2 |
| Appearance | White uniform crystalline powder without colored impurities |
| HPLC Purity | Reference Standard Grade ≥99.5%; Synthetic Grade ≥99.0% |
| Water Content (KF) | ≤0.20% |
| Melting Range | 134–136 °C |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-sealed amber glass vials / PE lined fiber drums |
| Storage Condition | Hermetically sealed dark dry warehouse below 25 °C; avoid direct sunlight and oxidants |
| Transportation Requirement | Common aromatic amide solid, moisture-proof sealed packaging |
| Shelf Life | 36 months under intact sealed packaging |
Safety Warning
Harmful aromatic amide powder. Dust irritates eyes, respiratory tract and skin; long-term repeated contact may cause adverse effects on hematopoietic system. All operations must be performed in ventilated fume hoods with dust respirators, chemical-resistant gloves and full-face safety goggles. Keep airtight storage away from light to prevent oxidative yellowing. Waste liquid needs organic solvent recovery and neutralization treatment; solid waste is classified as hazardous organic waste and must be disposed by licensed professional hazardous waste treatment facilities.
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