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2-Bromo-3'-chloropropiophenone
1. Basic Information
Name: 2-Bromo-3'-chloropropiophenone
CAS No.: 34911-51-8
Molecular Formula: C9H8BrClO
Molecular Weight: 247.52
Category: Halogenated aromatic ketone pharmaceutical synthetic intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale yellow crystalline powder
- Odor: Pungent aromatic ketone odor
- Solubility: Soluble in methanol, ethanol, acetone, ethyl acetate, dichloromethane; slightly soluble in hot water; insoluble in aliphatic alkanes
- Melting Range: 46–50 °C
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Aqueous Property: Weakly neutral lipophilic aromatic ketone, poor water solubility
Chemical Properties
- Molecular Structure: Propionphenone backbone with bromine substitution at α-position of alkyl chain and chlorine substituent at meta position of benzene ring
- α-Bromo Reactivity: Active alkyl bromide group undergoes nucleophilic substitution, amination and cyclization reactions for heterocyclic drug construction
- Aromatic Ketone Characteristic: Carbonyl group supports condensation, reduction and addition reactions
- Thermal Stability: Stable below 40 °C; long-term heating above melting point causes dehydrobromination and discoloration
- Photostability: Highly sensitive to ultraviolet light; long-time illumination accelerates decomposition and darkening
- Compatibility: Compatible with conventional polar organic solvents; incompatible with strong oxidants, concentrated alkaline reagents and ammonia
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key raw material for synthesizing anti-depressant, anti-inflammatory and heterocyclic API compounds via nucleophilic substitution and cyclization reactions
2. Fine Chemical Organic Synthesis Building Block
Precursor for halogenated aromatic heterocyclic derivatives and chiral synthetic intermediates
3. HPLC Reference Standard
Reference substance for detecting halogenated propiophenone intermediates in pharmaceutical production lines
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 34911-51-8 |
| Molecular Formula | C9H8BrClO |
| Appearance | Uniform pale yellow crystalline powder without foreign particles |
| HPLC Purity | API Intermediate Grade ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Melting Range | 46–50 °C |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-purged amber vacuum aluminum foil bags / PE-lined fiber drums |
| Storage Condition | Hermetically sealed dark warehouse below 25 °C; strictly isolated from light, alkaline substances and oxidants |
| Transportation Requirement | Light-sensitive halogenated aromatic ketone solid, fully sealed light-proof packaging |
| Shelf Life | 24 months under nitrogen-filled vacuum sealed storage |
Safety Warning
Corrosive irritant halogenated aromatic ketone powder. Dust and volatile vapor cause severe irritation to eyes, respiratory tract and skin; skin contact may produce blisters and allergic inflammation. All operations must be carried out inside ventilated chemical fume hoods with dust respirators, acid-resistant gloves and full-face safety goggles. Mandatory airtight dark storage to avoid photodegradation. Waste liquid requires organic solvent recovery and neutralization treatment; solid waste is classified as organic hazardous waste and must be disposed by licensed professional hazardous waste treatment facilities.
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