Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
4-Chloro-3-cyanopyridine
1. Basic Information
Name: 4-Chloro-3-cyanopyridine
CAS No.: 89284-61-7
Molecular Formula: C6H3ClN2
Molecular Weight: 138.55
Category: Halogenated cyano pyridine heterocyclic pharmaceutical intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Faint heterocyclic odor
- Solubility: Soluble in methanol, ethanol, acetone, THF, ethyl acetate; slightly soluble in hot water; insoluble in aliphatic alkanes
- Melting Range: 72–76 °C
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Aqueous Property: Neutral lipophilic nitrogen heterocycle, poor solubility in pure water
Chemical Properties
- Molecular Structure: Pyridine ring substituted with chlorine at C4 and cyano group at C3
- C-Cl Bond Reactivity: Aryl chloride participates in nucleophilic substitution, Buchwald-Hartwig coupling reactions for amine and ether derivatives synthesis
- Cyano Group Activity: Cyano can be hydrolyzed to amide/carboxylic acid, reduced to aminomethyl, or cyclized to construct nitrogen heterocycles
- Thermal Stability: Stable below 60 °C; prolonged heating above melting point causes slight decomposition and discoloration
- Photostability: Sensitive to UV light; long-term illumination generates oxidative impurities and darkens solid
- Compatibility: Compatible with common polar organic solvents; incompatible with strong oxidants, concentrated strong alkali and heavy metal catalysts
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key building block for kinase inhibitors, anti-inflammatory and anti-tumor APIs; widely used to construct pyridine-containing drug skeletons via cross-coupling and cyano derivatization
2. Agrochemical Intermediate
Raw material for high-efficiency pyridine fungicides and insecticides
3. HPLC Reference Standard
Reference substance for detection of chloro-cyanopyridine intermediates in chemical production lines
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 89284-61-7 |
| Molecular Formula | C6H3ClN2 |
| Appearance | Uniform white crystalline powder without visible foreign impurities |
| HPLC Purity | API Intermediate Grade ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Melting Range | 72–76 °C |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-purged amber vacuum aluminum foil bags / PE-lined fiber drums |
| Storage Condition | Hermetically sealed dark warehouse below 25 °C; isolated from light, oxidants and alkaline reagents |
| Transportation Requirement | Light-sensitive halogenated cyano pyridine solid, fully sealed light-proof packaging |
| Shelf Life | 24 months under nitrogen-filled vacuum sealed storage |
Safety Warning
Irritant cyano-containing halogenated pyridine powder. Dust causes severe irritation to eyes, respiratory tract and skin; prolonged skin contact may induce allergic dermatitis. All operations must be carried out inside ventilated chemical fume hoods with dust respirators, chemical-resistant gloves and full-face safety goggles. Airtight dark storage is required to prevent photooxidation degradation. Waste liquid requires organic solvent recovery and neutralization treatment; solid waste is classified as organic hazardous waste and must be disposed by licensed professional hazardous waste treatment facilities.
...
Product
