Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Cyclopenta(c)pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydro-, (1S,3aR,6aS)-
1. Basic Information
Name: Cyclopenta(c)pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydro-, (1S,3aR,6aS)-
Alias: Telaprevir, VX-950
CAS No.: 402957-28-2
Molecular Formula: C36H53N7O6
Molecular Weight: 679.85
Category: Chiral peptide macrocyclic antiviral active pharmaceutical ingredient (API)
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless polypeptide solid
- Solubility: Soluble in DMSO, methanol, ethanol, acetonitrile, dichloromethane; slightly soluble in ethyl acetate; insoluble in aliphatic alkanes and pure water
- Melting Behavior: Decomposes on heating without sharp melting point
- Hygroscopy: Slightly hygroscopic under high humidity environment
- Aqueous Property: Highly lipophilic multi-amide compound; only forms homogeneous solution with polar aprotic organic co-solvents
Chemical Properties
- Molecular Structure: Multi-chiral octahydrocyclopenta[c]pyrrole bicyclic scaffold linked with multiple peptide amide chains, containing pyrazine ring, cyclohexyl, tert-butyl, cyclopropylamide and diketone side chain; all chiral centers maintain fixed stereoconfiguration
- Amide Bond Characteristics: Multiple peptide amide bonds are stable under neutral and weakly acidic conditions; hydrolyze under strong alkaline heating to produce fragmented amino acid derivatives
- Ketone Group Reactivity: Vicinal diketone moiety can undergo nucleophilic addition and reductive derivatization reactions
- Thermal Stability: Long-term stable at 2–8 °C cold storage; rapid chiral epimerization and oxidative degradation at room temperature with prolonged exposure
- Photostability: Extremely sensitive to UV light; illumination triggers skeleton oxidation and racemization of chiral centers
- Compatibility: Compatible with anhydrous polar organic solvents; incompatible with strong oxidants, concentrated strong alkali, heavy metal ions and high-temperature acidic conditions
3. Main Application Fields
1. Antiviral Active Pharmaceutical Ingredient (Core Application)
Oral NS3/4A serine protease inhibitor for clinical treatment of chronic hepatitis C virus (HCV) infection; blocks viral protease activity to suppress HCV replication in human liver cells.
2. Pharmacopoeia Reference Standard
HPLC reference substance for impurity profiling and quality control during Telaprevir bulk drug production and finished pharmaceutical formulation testing.
3. Biochemical Research Reagent
Tool compound for in vitro HCV protease signal pathway research, antiviral pharmacology and drug resistance mechanism laboratory studies.
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 402957-28-2 |
| Molecular Formula | C36H53N7O6 |
| Appearance | Uniform white crystalline powder without colored impurities |
| HPLC Purity | Pharma API Grade ≥99.0%; Reference Standard ≥99.5% |
| Enantiomeric Excess (ee) | ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-purged amber glass vials / vacuum aluminum foil bags |
| Storage Condition | Hermetically sealed dark cold storage at 2–8 °C; strictly protected from light, moisture, oxidants and alkaline reagents |
| Transportation Requirement | Chiral light-sensitive antiviral API; cold-chain light-proof fully sealed transport |
| Shelf Life | 24 months under nitrogen-filled frozen cold storage |
Safety Warning
High-potency bioactive irritant polypeptide powder. Dust causes severe irritation to eyes, respiratory tract and skin; long-term skin contact may induce erythema and allergic dermatitis. All handling operations must be carried out inside ventilated chemical fume hoods with dust respirators, chemical-resistant gloves and full-face safety goggles. Mandatory low-temperature light-proof airtight storage to avoid chiral racemization and loss of antiviral activity. Waste liquid requires anhydrous solvent recovery and neutralization treatment; solid waste is classified as high-potency pharmaceutical hazardous waste and must be disposed by licensed professional hazardous waste treatment facilities.
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