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Lithium Aluminum Deuteride
1. Basic Information
Name: Lithium Aluminum Deuteride
Alias: LAD, Lithium tetradeuterioaluminate
CAS No.: 14128-54-2
Molecular Formula: LiAlD4
Molecular Weight: 41.99
Category: Heavy isotope-labeled strong reducing inorganic reagent, deuteration synthesis reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to light gray crystalline powder
- Odor: Odorless, releases irritating gas upon contact with water
- Solubility: Soluble in anhydrous ether, tetrahydrofuran; insoluble in hydrocarbon solvents, reacts violently with water, alcohol, protic solvents
- Melting Behavior: Decomposes before melting; thermal decomposition above 120 °C
- Hygroscopy: Extremely hygroscopic, instantly absorbs moisture from air
- Aqueous Property: Violent exothermic reaction with water, generates deuterium gas, lithium deuteroxide and aluminum deuteroxide
Chemical Properties
- Molecular Structure: Ionic compound composed of Li? cation and tetrahedral [AlD4]? anion; deuterium isotope replaces all hydrogen of lithium aluminum hydride
- Powerful Reduction: Strong reducing agent, reduces esters, amides, ketones, aldehydes, halides to corresponding deuterated alcohols, amines, alkanes
- Deuterium Source: Core reagent for introducing deuterium labels into organic molecules in isotope labeling chemistry
- Air Sensitivity: Spontaneously oxidizes in humid air; fine powder may ignite upon exposure to moisture
- Thermal Stability: Stable under anhydrous inert nitrogen/argon atmosphere below 80 °C; high temperature decomposes to release D? gas
- Compatibility: Only compatible with strictly anhydrous aprotic solvents; incompatible with water, alcohols, acids, oxidants, air, moisture
3. Main Application Fields
1. Isotope Labeled Drug Synthesis (Core Application)
Exclusive deuterated reduction reagent for preparing deuterated APIs, deuterated pharmacology research molecules; introduces deuterium atoms to modify metabolic stability of drugs
2. Organic Deuteration Chemistry Research
Laboratory preparation of deuterated alcohols, deuterated amines, deuterated alkane standards for NMR mass spectrometry analysis
3. Analytical Standard Reagent
Raw material for manufacturing deuterated reference substances for mass spectrometry and nuclear magnetic resonance testing
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 14128-54-2 |
| Molecular Formula | LiAlD4 |
| Appearance | Uniform white crystalline powder without gray oxide impurities |
| Purity | Synthesis Grade ≥98.0% |
| Deuterium Isotope Abundance | ≥99 atom % D |
| Water Content (KF) | ≤0.001% (strict anhydrous) |
| Residue on Ignition | ≤1.0% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Sealed metal can filled with nitrogen inert gas, vacuum aluminum foil inner bag |
| Storage Condition | Hermetically sealed inert gas storage, cool dry warehouse below 20 °C; strictly isolated from air, water, moisture, protic solvents |
| Transportation Requirement | Spontaneously dangerous reactive solid, Class 4.3 dangerous goods, fully airtight inert packaging, separated from water-based cargo |
| Shelf Life | 12 months under nitrogen-filled vacuum sealed storage |
Safety Warning
Extremely dangerous pyrophoric water-reactive solid. Contact with water, humid air, alcohol causes violent exothermic reaction, releases flammable deuterium gas that may ignite or explode. Dust irritates skin, eyes and respiratory tract; hydrolysis products are corrosive alkaline substances. All operations must be carried out in fully anhydrous inert glove box with argon/nitrogen protection, wearing flame-retardant protective suit, full-face gas mask, alkali-resistant thick gloves. Fire only uses dry sand, metal powder fire extinguisher; water, foam, CO? fire extinguishers are strictly prohibited. Waste disposal must be completed by professional hazardous waste institutions under anhydrous inert conditions via slow controlled quenching with anhydrous isopropanol. Classified as highly reactive dangerous hazardous waste.
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