Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Hydroxy-6-(trifluoromethyl)pyridine
1. Basic Information
Name: 2-Hydroxy-6-(trifluoromethyl)pyridine
Alias: 6-(Trifluoromethyl)-2-pyridinol, 2-oxo-6-trifluoromethyl-1,2-dihydropyridine
CAS No.: 34486-06-1
Molecular Formula: C6H4F3NO
Molecular Weight: 163.10
Category: Fluorinated pyridine heterocyclic pharmaceutical intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Faint heterocyclic odor
- Solubility: Soluble in methanol, ethanol, acetone, THF, DMSO; slightly soluble in hot water; insoluble in aliphatic alkanes
- Melting Range: 148–152 °C
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Aqueous Property: Weakly acidic, pyridone tautomer dominates in aqueous system
Chemical Properties
- Molecular Structure: Pyridine ring bearing hydroxyl at C2 and trifluoromethyl group at C6; exists mainly as 2-pyridone tautomer
- Tautomer characteristic: Interconvert between 2-hydroxypyridine and 2-pyridone; N-H bond enables N-alkylation, N-acylation reactions
- Trifluoromethyl group: Strong electron-withdrawing group, improves metabolic stability of target drugs; inert to common reduction/neutral reaction conditions
- Hydroxyl/pyridone reactivity: Can undergo O-alkylation, halogenation, sulfonylation to construct drug side chains
- Thermal Stability: Stable below 140 °C; prolonged heating above melting point leads to slight oxidative discoloration
- Photostability: Moderately sensitive to UV light; long-term irradiation produces trace fluorinated impurity
- Compatibility: Compatible with polar aprotic solvents; incompatible with strong oxidants, concentrated strong alkali
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key building block for kinase inhibitors, anti-inflammatory, anti-tumor small molecule APIs; trifluoromethyl pyridine core enhances bioavailability and half-life of drugs
2. Agrochemical Intermediate
Precursor for high-efficiency herbicides, fungicides with fluorinated pyridine skeleton
3. Organic Fluorescent Material Intermediate
Raw material for pyridine-based fluorescent probes and optoelectronic luminescent monomers
4. HPLC Reference Standard
Chromatographic standard for fluoropyridine intermediate purity detection
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 34486-06-1 |
| Molecular Formula | C6H4F3NO |
| Appearance | Uniform white crystalline powder without yellow impurities |
| HPLC Purity | Pharma Grade ≥99.0% |
| Water Content (KF) | ≤0.20% |
| Melting Range | 148–152 °C |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-purged amber vacuum aluminum foil bags / PE-lined fiber drums |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C; isolated from light and strong oxidants |
| Transportation Requirement | Light-sensitive fluoropyridine solid, light-proof sealed packaging |
| Shelf Life | 24 months under nitrogen-filled vacuum sealed storage |
Mild irritant fluoropyridine crystalline powder. Dust irritates eyes, respiratory tract and skin; long-term skin contact may trigger mild allergic redness for sensitive groups. All operations shall be carried out in ventilated fume hoods with dust respirators and chemical-resistant gloves. Avoid mixing with strong oxidants to prevent oxidative decomposition. Waste liquid recovered by solvent distillation and neutralized before discharge; solid waste belongs to organic hazardous waste and disposed by licensed professional hazardous waste treatment institutions.
...
Product
