Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Chlorothiazole
1. Basic Information
Name: 2-Chlorothiazole
Alias: 2-Chloro-1,3-thiazole
CAS No.: 3034-52-4
Molecular Formula: C3H2ClNS
Molecular Weight: 119.57
Category: Chlorinated sulfur-nitrogen five-membered heterocyclic fine chemical, pharmaceutical & agrochemical intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Colorless transparent flowing liquid
- Odor: Pungent heterocyclic sulfur odor, irritating to nose and throat
- Solubility: Miscible with ethanol, methanol, acetone, dichloromethane, toluene; slightly soluble in water
- Boiling Point: 146–149 °C
- Refractive Index nD20: 1.542–1.546
- Density (20℃): 1.35 g/cm3
- Hygroscopy: Slightly hygroscopic
- Aqueous Property: Weakly acidic, partial hydrolysis under long-term aqueous storage
Chemical Properties
- Molecular Structure: Thiazole ring with chlorine substitution at C2 position; C2-Cl bond has high reactivity for nucleophilic substitution
- Nucleophilic substitution: Undergoes amination, alkoxylation, cyanation, thiolation to build thiazole drug skeletons
- Aromatic ring characteristics: Electrophilic substitution occurs at C4/C5 positions under mild conditions
- Thermal Stability: Stable below 130 °C; overheating easily volatilizes and releases irritating vapor
- Photostability: Sensitive to strong UV light; long irradiation turns pale yellow and produces trace chlorinated impurities
- Compatibility: Compatible with common anhydrous organic solvents; incompatible with strong alkalis, strong reducing agents, metal alkoxides
3. Main Application Fields
1. Pharmaceutical Intermediate (Core Application)
Key raw material for antibacterial, anti-inflammatory, anti-tumor small molecule APIs; thiazole core improves drug metabolic stability and target binding ability
2. Agrochemical Intermediate
Precursor for high-efficiency thiazole fungicides, insecticides and plant growth regulators
3. Organic Synthetic Building Block
Synthesis of thiazole fluorescent probes, rubber vulcanization accelerators, metal surface treatment additives
4. GC Reference Standard
Chromatographic standard for thiazole heterocycle purity detection
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 3034-52-4 |
| Molecular Formula | C3H2ClNS |
| Appearance | Colorless clear liquid without yellow suspended matter |
| GC Purity | Synthesis Grade ≥99.0% |
| Water Content (KF) | ≤0.10% |
| Distillation Range | 145–150 ℃ ≥95% |
| Residue on Ignition | ≤0.01% |
| Single Unknown Impurity | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Sealed nitrogen-filled galvanized iron drum / amber plastic barrel |
| Storage Condition | Hermetically sealed cool dark warehouse below 25 ℃; away from fire, heat sources and alkaline raw materials |
| Transportation Requirement | Irritant weakly flammable heterocyclic liquid, Class 3 flammable liquid, light-proof airtight packaging, separated from strong alkali cargo |
| Shelf Life | 24 months under nitrogen sealed storage |
Safety Warning
Irritant flammable heterocyclic liquid. Vapor severely stimulates eyes, respiratory tract and skin; direct contact causes burning, redness and pain. All operations must be carried out in fully ventilated fume hood with organic vapor respirator, chemical-resistant goggles and nitrile gloves. Keep away from open flame, static electricity and heat sources. Fire fighting uses dry powder, CO? fire extinguisher; water flushing only for skin/eye dilution after leakage. Waste liquid recovered by rectification; residual halogen-containing organic waste disposed by licensed hazardous waste institutions.
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