Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Levodopa
1. Basic Information
Name: Levodopa
Alias: L-3,4-Dihydroxyphenylalanine
CAS No.: 59-92-7
Molecular Formula: C9H11NO4
Molecular Weight: 197.19
Category: Chiral aromatic amino acid, Parkinson's disease therapeutic API
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in water; soluble in dilute acid, dilute alkali; insoluble in ethanol, acetone, ether
- Melting Range: 275–277 °C (decomposes)
- Hygroscopy: Slightly hygroscopic in high humidity environment
- Aqueous property: Amphoteric substance, aqueous solution weak acidic, easy to oxidize and turn dark when exposed to air
Chemical Properties
- Molecular structure: L-chiral phenylalanine derivative with two ortho hydroxyl groups on benzene ring
- Catechol oxidation characteristic: Two phenolic hydroxyl groups are extremely susceptible to oxidation by air, light, oxidants to generate quinone dark impurities
- Amphoteric reaction: Amino and carboxyl groups can form salts with acid and alkali; capable of Boc/Fmoc protection, esterification, amide condensation
- Optical stability: Stable under sealed dark storage; high temperature and strong alkaline environment will cause chiral racemization
- Thermal stability: Stable below 240 °C; decomposes above melting point to release ammonia and phenolic volatiles
- Compatibility: Compatible with weakly acidic aqueous buffer; incompatible with strong oxidants, heavy metal ions, strong alkali
3. Main Application Fields
1. Parkinson's Disease API Raw Material (Core Application)
First-line clinical drug for Parkinson syndrome; crosses blood-brain barrier and converts to dopamine to relieve limb tremor, stiffness and motor dysfunction
2. Biochemical Research Reagent
Laboratory research tool for dopamine synthesis and nerve signal transduction pathway study
3. Pharmacopoeia Reference Standard
HPLC standard substance for enantiomer and related substance inspection in levodopa production QC
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 59-92-7 |
| Molecular Formula | C9H11NO4 |
| Appearance | Uniform white crystal without brown oxidation impurities |
| HPLC Purity | Pharma Grade ≥99.0% |
| Enantiomeric Excess ee | ≥99.8% |
| Specific Optical Rotation [α]D20 | -11.5° ~ -13.0° (1mol/L HCl) |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber vacuum aluminum foil bags / PE lined fiber drums |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, fully light-proof, isolate air and oxidants to prevent oxidation discoloration |
| Transportation Requirement: Light-sensitive, easily oxidized chiral amino acid solid, moisture-proof and light-proof sealed packaging | |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Low acute toxicity mild irritant pharmaceutical powder. Dust irritates eyes, nasal cavity and respiratory tract; long-term skin contact easily causes mild allergic itching. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile gloves. It is a prescription drug, oral administration must follow medical advice; excessive intake may cause nausea, arrhythmia and dyskinesia. Waste liquid neutralized before discharge; solid waste classified as pharmaceutical hazardous waste and disposed by licensed professional institutions.
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