Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
BETA-PSEUDOURIDINE
1. Basic Information
Name: β-Pseudouridine
Alias: Pseudouridine, Ψ-Uridine, 5-(β-D-Ribofuranosyl)uracil
CAS No.: 1445-07-4
Molecular Formula: C9H12N2O6
Molecular Weight: 244.20
Category: Modified natural nucleoside, mRNA vaccine raw material, biochemical research reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Soluble in hot water; slightly soluble in heated methanol; insoluble in ethanol, acetone, ether
- Melting Range: 222 °C (decomposes)
- Density (predicted): 1.641 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous Property: Weakly alkaline aqueous solution, stable neutral storage
Chemical Properties
- Molecular structure: C-glycoside isomer of uridine; ribose and uracil connected by C-C bond instead of conventional N-C glycosidic bond
- Glycosidic bond stability: C-C bond far more stable than uridine N-glycosidic bond, resistant to nuclease degradation
- Multiple hydroxyl groups: Ribose hydroxyls can undergo acylation, silylation protection for nucleic acid synthesis
- Thermal stability: Stable below 210 °C; high-temperature decomposition releases sugar and pyrimidine fragments
- Photostability: Slightly sensitive to long-term UV irradiation, trace yellow impurities generated
- Compatibility: Compatible with aqueous phosphate buffer, anhydrous polar solvents; incompatible with strong oxidants, concentrated strong alkali
3. Main Application Fields
1. mRNA Vaccine Core Raw Material (Core Application)
Replace uridine in mRNA sequences to enhance mRNA stability, reduce innate immune stimulation, improve intracellular protein expression efficiency
2. Biochemical & RNA Research Reagent
Study RNA modification, tRNA/rRNA structural stabilization, pseudouridine synthase enzyme mechanism; universal RNA modification standard sample
3. Tumor Metabolite Biomarker
Detect urinary β-pseudouridine for auxiliary diagnosis of malignant tumor proliferation state
4. Nucleic Acid Probe & Synthetic Oligonucleotide
Synthesize stable modified RNA primers, guide RNA to extend in-vivo metabolic half-life
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 1445-07-4 |
| Molecular Formula | C9H12N2O6 |
| Appearance | Uniform white crystal without discoloration |
| HPLC Purity | Biotech Grade ≥99.0%; Vaccine Grade ≥99.5% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bags / low-temperature PE lined fiber drums |
| Storage Condition | Hermetically sealed, 2–8 °C cold storage, full light shielding, isolate moisture and oxidants |
| Transportation Requirement | Cold-chain light-sensitive nucleoside solid, moisture-proof light-proof sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed low-temperature storage |
Safety Warning
Low acute toxicity mild irritant nucleoside powder. Dust irritates eyes, nasal tract and respiratory mucosa; long-term skin contact may trigger mild allergic itching. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile chemical-resistant gloves. For laboratory research raw material only, prohibited direct human injection/oral administration. Waste liquid neutralized before discharge; solid waste classified as biological biochemical hazardous waste disposed by licensed professional institutions.
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