Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Metoclopramide hydrochloride
1. Basic Information
Name: Metoclopramide hydrochloride
Alias: 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride
CAS No.: 54143-57-6
Molecular Formula: C14H23Cl2N3O2
Molecular Weight: 336.26
Category: Gastrointestinal therapeutic API, pharmaceutical raw material, veterinary drug intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slightly bitter taste
- Solubility: Freely soluble in water, methanol; soluble in ethanol; slightly soluble in acetone; insoluble in ether, chloroform
- Melting Point: 182–186 ℃
- Density (predicted): 1.18 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous property: Weakly acidic aqueous solution, stable under pH 3–7
Chemical Properties
- Molecular structure: Substituted benzamide hydrochloride salt, contains primary amino group, amide bond, tertiary amine side chain and chlorine substituent
- Amide hydrolysis: Amide bond breaks under strong acid/alkali heating to produce benzoic acid derivative and diethylaminoethylamine
- Aromatic amine characteristic: Amino group undergoes diazotization reaction for impurity detection and derivative synthesis
- Thermal stability: Stable below 120 ℃; high temperature decomposes and releases amine volatile substances
- Photostability: Light-sensitive, long-term UV irradiation turns pale yellow
- Compatibility: Compatible with neutral aqueous buffer, low-carbon alcohols; incompatible with strong oxidants, concentrated strong alkali
3. Main Application Fields
1. Gastrointestinal API (Core Application)
Raw material for antiemetic, gastric motility-promoting oral tablets, injection solutions; treats nausea, vomiting, gastroparesis, reflux esophagitis
2. Veterinary Pharmaceutical Raw Material
Livestock and poultry anti-vomiting, gastrointestinal regulation veterinary formulations
3. Pharmaceutical Intermediate
Synthesize other benzamide digestive system drug derivatives
4. Pharmacology Research Reagent
Dopamine D2 receptor antagonist standard substance for laboratory pharmacological experiments
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 54143-57-6 |
| Molecular Formula | C14H23Cl2N3O2 |
| Appearance | Uniform white crystal without yellow oxidation impurities |
| HPLC Purity | Pharma Grade ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 1kg/5kg vacuum aluminum foil bag, 25kg light-proof PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, full light shielding, isolate alkaline and oxidizing substances |
| Transportation Requirement | Light-sensitive pharmaceutical hydrochloride powder, moisture-proof sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed storage |
Safety Warning
Low-toxic irritant pharmaceutical crystalline powder. Dust irritates eyes, nasal tract and respiratory mucosa; long-term skin contact may cause mild allergic itching. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile gloves. Prescription drug raw material, excessive intake may cause extrapyramidal reactions. Waste liquid neutralized before discharge; solid waste classified as halogen-containing pharmaceutical hazardous waste disposed by licensed professional institutions.
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