Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-FLUORO-3-NITROBENZOIC ACID
1. Basic Information
Name: 2-Fluoro-3-nitrobenzoic acid
Alias: 2-Fluoro-3-nitrobenzenecarboxylic acid
CAS No.: 317-46-4
Molecular Formula: C7H4F1N1O4
Molecular Weight: 186.11
Category: Fluorinated aromatic fine chemical, pharmaceutical synthetic intermediate, organic building block
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale yellow crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in cold water; soluble in hot water, ethanol, methanol, acetone, ethyl acetate; insoluble in petroleum ether
- Melting Point: 170–173 ℃
- Density (predicted): 1.57 g/cm3
- Hygroscopy: Non-hygroscopic under normal humidity
- Aqueous property: Weakly acidic due to carboxylic acid group, dissolves in dilute alkaline solution to form soluble benzoate salt
Chemical Properties
- Molecular structure: Monofluorinated benzoic acid with ortho-fluoro and meta-nitro substituents on benzene ring, contains carboxyl, nitro and fluorine leaving group
- Carboxyl reaction: Carboxylic acid group undergoes esterification, amidation, decarboxylation to construct drug molecular fragments
- Aromatic nucleophilic substitution: Ortho fluorine atom has high reactivity, easy to be substituted by amines, alcohols and thiols
- Nitro reduction: Nitro group can be reduced to primary amine to prepare amino fluoro benzoic acid intermediates
- Thermal stability: Stable below 150 ℃; prolonged heating above melting point causes slight decomposition
- Photostability: Slightly light-sensitive, long-term UV irradiation deepens yellow color
- Compatibility: Compatible with polar organic solvents, weak alkaline aqueous solution; incompatible with strong reducing agents, strong oxidants, concentrated strong alkali
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key fluorinated building block for antibiotics, anti-inflammatory drugs, kinase inhibitors and central nervous system therapeutic agents
2. Fine Organic Synthesis Raw Material
Raw material for liquid crystal materials, fluorescent dye intermediates and heterocyclic compound synthesis
3. Laboratory Research Reagent
Aromatic fluorine substitution reaction substrate for organic chemistry research
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 317-46-4 |
| Molecular Formula | C7H4F1N1O4 |
| Appearance | Uniform pale yellow crystal without dark impurities |
| HPLC Purity | Pharma Intermediate Grade ≥98.0% |
| Melting Point | 170–173 ℃ |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 10g/100g vacuum aluminum foil bag, 25kg light-proof PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, full light shielding, isolate strong reducing substances |
| Transportation Requirement | Light-sensitive fluorinated aromatic solid powder, moisture-proof sealed packaging |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Low-toxic irritant aromatic crystalline powder. Dust irritates eyes, nasal tract and respiratory mucosa; long-term skin contact causes mild dry itching. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile chemical-resistant gloves. Avoid mixing with strong reducing agents to prevent violent redox reaction. Waste liquid neutralized with alkali before discharge; solid waste classified as fluorine-containing fine chemical hazardous waste disposed by licensed professional institutions.
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