Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Heparin calcium
1. Basic Information
Name: Heparin calcium
Alias: Calcium heparinate, Heparin calcium salt
CAS No.: 37270-89-6
Molecular Formula: (C12H16CaN2S3O26)n
Molecular Weight: Macromolecular polysaccharide mixture, average molecular weight 6000–20000 Da
Category: Anticoagulant biopharmaceutical API, polysaccharide pharmaceutical raw material, clinical anticoagulant
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white amorphous powder
- Odor: Odorless
- Solubility: Freely soluble in water; insoluble in ethanol, acetone, ether and other organic solvents
- Density (predicted): 1.52 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous property: Weakly acidic aqueous solution, stable in pH 4–8 aqueous buffer
Chemical Properties
- Molecular structure: Heterogeneous linear glycosaminoglycan polysaccharide, contains multiple sulfate groups, carboxyl groups, combined with calcium ions
- Anticoagulant mechanism: Combine with antithrombin III to inhibit blood coagulation factors, block thrombus formation
- Ion exchange characteristic: Calcium ions can be exchanged with sodium, potassium and other metal cations to prepare heparin sodium, heparin potassium
- Thermal stability: Stable below 80 ℃; long-term high temperature heating leads to polysaccharide chain degradation and reduced anticoagulant activity
- Photostability: Light-sensitive, long-term UV irradiation will degrade polysaccharide and decrease efficacy
- Compatibility: Compatible with neutral aqueous solution; incompatible with strong oxidants, concentrated strong acid, strong alkaline substances
3. Main Application Fields
1. Clinical Anticoagulant API (Core Application)
Raw material for subcutaneous injection formulations; prevent and treat deep vein thrombosis, pulmonary embolism, thrombosis during hemodialysis and cardiovascular surgery
2. Biochemical Research Reagent
In vitro blood anticoagulant for laboratory blood sample preservation, cell culture additive
3. Medical Auxiliary Raw Material
Surface anticoagulant coating modifier for medical catheters, blood contact medical devices
4. Veterinary Drug Raw Material
Antithrombotic raw material for animal cardiovascular disease treatment preparations
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 37270-89-6 |
| Molecular Formula | (C12H16CaN2S3O26)n |
| Appearance | Uniform off-white powder without discoloration impurities |
| Anticoagulant Activity | ≥150 IU/mg (Pharma Grade) |
| Water Content (KF) | ≤8.00% |
| Residue on Ignition | 28.0%–41.0% |
| Heavy Metals (Pb) | ≤10 ppm |
| Calcium Content | 9.5%–11.5% |
| Packaging | 1kg/5kg vacuum aluminum foil bag, 25kg light-proof PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse 2–8 ℃, full light shielding, isolate acid and oxidizing substances |
| Transportation Requirement | Light-sensitive polysaccharide pharmaceutical powder, moisture-proof low-temperature sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed low-temperature storage |
Safety Warning
Low-toxic pharmaceutical polysaccharide powder. Dust irritates eyes, nasal tract and respiratory mucosa; improper systemic absorption may cause bleeding risk. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile gloves. Prescription anticoagulant raw material, excessive use leads to coagulation dysfunction and bleeding tendency. Waste liquid neutralized before discharge; solid waste classified as biological pharmaceutical hazardous waste disposed by licensed professional institutions.
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