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1-Methylindole
1. Basic Information
Name: 1-Methylindole
Alias: N-Methylindole, 1-Methyl-1H-indole
CAS No.: 603-76-9
Molecular Formula: C9H9N1
Molecular Weight: 131.17
Category: Indole heterocyclic synthetic intermediate, flavor raw material, pharmaceutical building block
2. Physical and Chemical Properties
Physical Properties
- Appearance: Colorless to light yellow transparent oily liquid
- Odor: Rich jasmine, floral characteristic aroma
- Solubility: Miscible with ethanol, acetone, ether, toluene; slightly soluble in water
- Melting Point: ?20 ℃
- Boiling Point: 237–239 ℃
- Density (20℃): 1.047–1.051 g/cm3
- Refractive Index nD20: 1.594–1.597
- Flash Point: 101 ℃
- Hygroscopy: Non-hygroscopic
- Aqueous property: Neutral oily liquid, insoluble in water, stable under neutral and weak acid conditions
Chemical Properties
- Molecular structure: Indole heterocycle with methyl substitution on nitrogen atom, fully aromatic conjugated system
- Electrophilic substitution: C3 position of indole ring has high reactivity, easy to undergo Friedel-Crafts, halogenation, condensation reactions
- Thermal stability: Stable below 180 ℃; long-time high temperature heating causes slight polymerization and color deepening
- Photostability: Light-sensitive, UV irradiation accelerates oxidation, liquid turns dark yellow-brown
- Compatibility: Compatible with oil-soluble solvents, most organic synthesis raw materials; incompatible with strong oxidants, concentrated strong acid
3. Main Application Fields
1. Fragrance & Flavor Raw Material (Core Application)
Jasmine floral essence for daily cosmetics, soap, perfume, tobacco flavor; enhances soft floral aroma
2. Pharmaceutical Synthetic Intermediate
Key indole building block for anti-inflammatory drugs, antidepressants, antitumor and anti-microbial heterocyclic APIs
3. Fine Chemical Reagent
Raw material for fluorescent dyes, photosensitive materials, organic electronic functional compounds
4. Organic Chemistry Research Substrate
Model compound for indole electrophilic substitution reaction laboratory experiments
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 603-76-9 |
| Molecular Formula | C9H9N1 |
| Appearance | Colorless to pale yellow clear liquid without sediment |
| GC Purity | Fragrance/Pharm Intermediate Grade ≥98.0% |
| Water Content (KF) | ≤0.10% |
| Chroma (APHA) | ≤150 |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 100ml/1L amber fluorinated bottle, 25kg PE plastic drum, 200kg iron drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, full light shielding, isolate oxidizing substances |
| Transportation Requirement | Light-sensitive indole heterocyclic liquid, sealed anti-oxidation light-proof packaging |
| Shelf Life | 24 months under nitrogen sealed storage |
Safety Warning
Low-toxic irritant aromatic heterocyclic liquid. Vapor irritates eyes, respiratory tract and skin; long-term skin contact causes mild allergic itching. All operations must be carried out in ventilated fume hood with nitrile gloves and splash-proof goggles. Strictly avoid contact with strong oxidants to prevent oxidative discoloration. Waste liquid diluted and neutralized before discharge; residual liquid treated as general organic hazardous waste by licensed professional institutions.
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