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Lysine clonixinate
1. Basic Information
Name: Lysine clonixinate
Alias: Clonixin lysine salt, 2-(3-chloro-o-toluidino)nicotinic acid L-lysine salt
CAS No.: 55837-30-4
Molecular Formula: C13H12ClN2O2 · C6H14N2O2 = C19H26ClN4O4
Molecular Weight: 410.89
Category: Nonsteroidal anti-inflammatory API, analgesic pharmaceutical raw material, antipyretic drug intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to pale off-white crystalline powder
- Odor: Odorless, slight bitter taste
- Solubility: Freely soluble in water, methanol; soluble in ethanol; slightly soluble in acetone; insoluble in ether, chloroform
- Melting Point: 189–193 ℃
- Density (predicted): 1.28 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity environment
- Aqueous property: Weak neutral aqueous solution, stable within pH range 4–8
Chemical Properties
- Molecular structure: Ionic salt formed by clonixin (chloro-substituted anilinonicotinic acid) and L-lysine amino acid; contains carboxylic acid, aromatic amine, pyridine ring and chlorine substituent
- Salt dissociation: Dissociates into clonixin anion and lysine cation after dissolving in water, improves water solubility compared with clonixin free acid
- Aromatic amine feature: Amino group on benzene ring can undergo diazotization reaction for impurity detection
- Thermal stability: Stable below 150 ℃; long-term heating above melting point will cause partial decomposition and discoloration
- Photostability: Light-sensitive, long-term UV irradiation turns faint yellow
- Compatibility: Compatible with neutral aqueous buffer, low-carbon alcohols; incompatible with strong oxidants, concentrated strong alkali
3. Main Application Fields
1. Analgesic & Anti-inflammatory API (Core Application)
Raw material for oral tablets, injection solutions; used for relief of mild to moderate pain, inflammatory swelling, fever, dysmenorrhea, musculoskeletal inflammation
2. Pharmaceutical Synthetic Intermediate
Precursor for other nicotinic acid derivative anti-inflammatory analgesic drugs
3. Veterinary Pharmaceutical Raw Material
Anti-pain and anti-inflammatory auxiliary raw material for animal veterinary formulations
4. Pharmacology Research Reagent
Standard substance for NSAID analgesic activity screening laboratory experiments
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 55837-30-4 |
| Molecular Formula | C19H26ClN4O4 |
| Appearance | Uniform white crystal powder without yellow oxidation impurities |
| HPLC Purity | Pharma Grade ≥99.0% |
| Melting Point | 189–193 ℃ |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 1kg/5kg vacuum aluminum foil bag, 25kg light-proof PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, full light shielding, isolate alkaline and oxidizing substances |
| Transportation Requirement | Light-sensitive chlorinated pharmaceutical salt powder, moisture-proof sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed storage |
Safety Warning
Low-toxic irritant chlorinated pharmaceutical crystalline powder. Dust irritates eyes, nasal tract and respiratory mucosa; long-term skin contact may cause mild allergic itching. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile chemical-resistant gloves. Prescription anti-inflammatory raw material, excessive intake may cause gastrointestinal mucosal irritation. Waste liquid neutralized before discharge; solid waste classified as halogen-containing pharmaceutical hazardous waste disposed by licensed professional institutions.
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