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1-bromo-9H-carbazole
1. Basic Information
Name: 1-bromo-9H-carbazole
Alias: 1-Bromocarbazole
CAS No.: 16807-11-7
Molecular Formula: C12H8BrN
Molecular Weight: 246.10
Category: Brominated carbazole heterocyclic intermediate, organic photoelectric material monomer, pharmaceutical synthetic building block
2. Physical and Chemical Properties
Physical Properties
- Appearance: Off-white to light pale yellow crystalline powder
- Odor: Odorless
- Solubility: Soluble in dichloromethane, chloroform, toluene, THF, DMF; slightly soluble in methanol and ethanol; insoluble in water and aliphatic alkanes
- Melting Point: 148–152 ℃
- Density (predicted): 1.53 g/cm3
- Hygroscopy: Non-hygroscopic under normal humidity
- Aqueous property: Insoluble in water, neutral solid, stable in neutral and weak acid environment
Chemical Properties
- Molecular structure: Carbazole fused aromatic heterocycle with bromine substitution at the 1-position, contains reactive NH group and aryl bromide site
- Aryl halide coupling: C1 bromine atom is active for Suzuki, Buchwald, Sonogashira cross-coupling reactions to construct conjugated organic molecules
- N-H reactivity: The nitrogen hydrogen on carbazole ring can be alkylated, arylated to modify molecular solubility and photoelectric performance
- Thermal stability: Stable below 140 ℃; above melting point slight sublimation occurs, long-time high temperature leads to partial decomposition
- Photostability: Slightly light-sensitive, long-term UV irradiation turns deeper yellow
- Compatibility: Compatible with anhydrous polar/non-polar organic solvents; incompatible with strong oxidants, strong reducing agents, concentrated strong alkali
3. Main Application Fields
1. Organic Optoelectronic Material Intermediate (Core Application)
Key raw material for OLED hole transport materials, organic photoconductors, fluorescent dyes, organic semiconductor functional molecules
2. Fine Pharmaceutical Synthetic Block
Precursor for anti-tumor, anti-inflammatory, central nervous system carbazole-based drug APIs
3. Organic Synthesis Laboratory Reagent
Standard substrate for aromatic cross-coupling reaction research in synthetic chemistry labs
4. Dye & Pigment Raw Material
Intermediate for high light fastness conjugated fluorescent dyes
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 16807-11-7 |
| Molecular Formula | C12H8BrN |
| Appearance | Uniform pale off-white crystal without brown impurities |
| HPLC Purity | Optoelectronic Grade ≥99.0%; Synthetic Grade ≥98.0% |
| Melting Point | 148–152 ℃ |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 10g/100g vacuum aluminum foil bag, 25kg light-proof PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, full light shielding, isolate oxidants and strong reducing substances |
| Transportation Requirement | Light-sensitive brominated heteroaromatic powder, moisture-proof light-proof sealed packaging |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Low-toxic irritant brominated aromatic heterocyclic powder. Dust irritates eyes, nasal tract and respiratory mucosa; long-term skin contact may cause mild dry itching. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile chemical-resistant gloves. Avoid mixing with strong reducing agents to trigger exothermic debromination reaction. Waste liquid neutralized with dilute acid before discharge; solid waste classified as bromine-containing heterocyclic fine chemical hazardous waste disposed by licensed professional institutions.
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