Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Cosyntropin
1. Basic Information
Name: Cosyntropin
Alias: Tetracosactide, 1-24 Corticotropin, H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
CAS No.: 16960-16-0
Molecular Formula: C136H210N40O31S
Molecular Weight: 2933.48
Category: Synthetic adrenocorticotropic polypeptide API, endocrine diagnostic reagent, peptide pharmaceutical raw material
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white lyophilized crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water, dilute acetic acid; slightly soluble in methanol; insoluble in ethanol, acetone, ether, alkane solvents
- Melting Point: Decomposes above 225 ℃
- Density (predicted): 1.42 g/cm3
- Hygroscopy: Strongly hygroscopic under high humidity
- Aqueous property: Amphipathic polypeptide, weakly acidic aqueous solution, stable at pH 3–7
Chemical Properties
- Molecular structure: Synthetic 24-amino-acid linear polypeptide, retains the active functional fragment of natural ACTH, contains methionine sulfide, multiple lysine and arginine basic residues, phenolic hydroxyl groups
- Peptide bond hydrolysis: Peptide chains hydrolyze into free amino acids under strong acid/alkali heating or protease catalysis, losing biological activity
- Oxidation susceptibility: Methionine residue easily oxidized to methionine sulfoxide by air and light, reducing hormone activity
- Thermal stability: Stable below 60 ℃; high temperature sterilization causes peptide chain cleavage and activity decline
- Photostability: Highly light-sensitive, UV irradiation accelerates oxidation and discoloration
- Compatibility: Compatible with aqueous buffer, low-carbon alcohols; incompatible with strong oxidants, concentrated strong acid, strong protease
3. Main Application Fields
1. Clinical Endocrine Diagnostic API (Core Application)
Raw material for injection diagnostic preparations; used for adrenal cortex function stimulation test to distinguish primary and secondary adrenal insufficiency
2. Peptide Pharmaceutical Intermediate
Synthetic precursor of long-acting sustained-release tetracosactide acetate formulations
3. Pharmacology Research Reagent
Standard polypeptide for adrenal cortical hormone secretion mechanism laboratory research, cell culture stimulant
4. Biochemical Reference Standard
HPLC calibration standard for adrenocorticotropic peptide detection
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 16960-16-0 |
| Molecular Formula | C136H210N40O31S |
| Appearance | Uniform white lyophilized powder without yellow oxidized impurities |
| HPLC Purity | Pharma Injection Grade ≥98.0% |
| Biological Activity | ≥800 IU/mg |
| Water Content (KF) | ≤3.00% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Microbiological Limit | Sterile raw material, no pathogenic bacteria |
| Packaging | 1mg/10mg vacuum aluminum foil vial, 1g/5kg low-temperature light-proof vacuum bag, 25kg PE lined freeze-drying fiber drum |
| Storage Condition | Hermetically sealed low-temperature warehouse 2–8 ℃, full light shielding, isolate air and oxidants |
| Transportation Requirement | Hygroscopic light-sensitive polypeptide powder, cold-chain light-proof sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed refrigerated storage |
Safety Warning
Low-toxic irritant polypeptide lyophilized powder. Dust irritates eyes, nasal tract and respiratory tract; accidental injection may trigger excessive cortisol secretion, hypertension and electrolyte disturbance. All operations must be carried out in sterile ventilated fume hood with dust-proof respirator and sterile nitrile chemical-resistant gloves. Strictly avoid contact with strong oxidants to prevent methionine oxidation and loss of biological activity. Waste liquid neutralized before discharge; solid waste classified as biological peptide pharmaceutical hazardous waste disposed by licensed professional institutions.
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