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DL-2-Amino-4-methylpentanoic acid
1. Basic Information
Name: DL-2-Amino-4-methylpentanoic acid
Alias: DL-Leucine, DL-Leu, Racemic leucine
CAS No.: 328-39-2
Molecular Formula: C6H13NO2
Molecular Weight: 131.17
Category: Racemic essential amino acid, biochemical reagent, pharmaceutical chiral resolution raw material, food additive intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slightly bitter taste
- Solubility: Soluble in hot water, slightly soluble in cold water; insoluble in ethanol, acetone, ether, aromatic solvents
- Melting Point: 290–293 ℃ (decomposes)
- Specific Rotation [α]???: 0° (racemic mixture, no optical activity)
- Density (predicted): 1.07 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous property: Amphoteric compound, aqueous solution is near neutral, isoelectric point pH≈6.0
Chemical Properties
- Molecular structure: Racemic mixture of L-leucine and D-leucine, contains α-amino group and carboxyl group, isobutyl side chain
- Amphoteric ionization: Reacts with acid to form amino acid salts; reacts with alkali to form carboxylate salts
- Peptide condensation: Carboxyl and amino groups can undergo condensation to form peptide bonds for polypeptide synthesis
- Chiral resolution: Can be split into pure L-leucine and D-leucine via chiral resolving agents
- Maillard reaction: Heating with sugars/aldehydes produces yellow-brown flavor substances
- Thermal stability: Stable below 200 ℃; high temperature above melting point decomposes to release ammonia
- Photostability: Slightly light-sensitive, long-term strong light storage turns faint yellow
- Compatibility: Compatible with water, dilute acid/alkali; incompatible with strong oxidants
3. Main Application Fields
1. Chiral Resolution Raw Material (Core Application)
Racemic leucine used for laboratory chiral separation research, preparation of single chiral D/L-leucine monomers
2. Biochemical Laboratory Reagent
Standard substrate for amino acid metabolism, protease activity screening experiments
3. Pharmaceutical Intermediate
Raw material for synthetic racemic peptide drugs, cosmetic amino acid moisturizing additives
4. Feed & Food Additive Intermediate
Nutritional supplement precursor for animal feed compound amino acid formulations
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 328-39-2 |
| Molecular Formula | C6H13NO2 |
| Appearance | Uniform white crystal powder without yellow agglomeration |
| HPLC Purity | Biochemical Grade ≥99.0% |
| Loss on Drying | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.05% |
| Optical Rotation | 0° ± 0.2° (racemic confirmation) |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 10g/100g vacuum aluminum foil bag, 1kg/5kg light-proof fiber drum lined with PE film |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, light shielding, isolate humid air and oxidants |
| Transportation Requirement | Slightly hygroscopic amino acid powder, moisture-proof sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed storage |
Safety Warning
Low-toxic mild irritant amino acid powder. Dust may irritate eyes and nasal mucosa; no acute toxicity to human body. All operations carried out in ventilated fume hood with dust mask and nitrile gloves. Avoid long-term contact with strong oxidants to prevent discoloration. Waste liquid biodegradable after dilution; solid waste belongs to general biochemical waste.
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