Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Vitamin B12
1. Basic Information
Name: Vitamin B12
Alias: Cyanocobalamin
CAS No.: 68-19-9
Molecular Formula: C63H88CoN14O14P
Molecular Weight: 1355.38
Category: Cobalt-containing water-soluble vitamin, pharmaceutical API, food nutrition fortifier, feed additive, biochemical culture reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: Dark red crystalline powder
- Odor: Odorless, slight characteristic faint taste
- Solubility: Freely soluble in water, methanol; slightly soluble in ethanol; insoluble in acetone, ether, benzene, petroleum ether
- Melting Point: Decomposes above 210 ℃
- Specific Rotation [α]???: ?59° ~ ?62° (aqueous solution)
- Density (predicted): 1.31 g/cm3
- Hygroscopy: Moderately hygroscopic under high humidity
- Aqueous property: Neutral to weakly acidic aqueous solution, stable in pH 4–6; loses activity rapidly under alkaline conditions
Chemical Properties
- Molecular structure: Giant complex cobalt porphyrin derivative, central cobalt ion coordinated with corrin ring, contains cyano group, multiple amide, phosphate and sugar side chains
- Redox sensitivity: Easily reduced to cob(II)alamin or oxidized under strong oxidants, leading to loss of physiological activity
- Photolysis characteristic: Extremely light-sensitive; UV/visible light rapidly decomposes the corrin ring, solution fades from red to pale pink
- Thermal stability: Stable below 80 ℃; high-temperature sterilization, boiling under alkaline environment severely deactivates vitamin B12
- Metal ion interference: Heavy metal ions (Fe3?, Cu2?) accelerate decomposition and activity attenuation
- Compatibility: Compatible with weak acidic buffer, vitamin B complex; incompatible with strong alkali, strong oxidants, heavy metal salts, reducing agents
3. Main Application Fields
1. Pharmaceutical API (Core Application)
Raw material for oral tablets, injections; treats megaloblastic anemia, peripheral neuritis, neurological dysfunction, malabsorption syndrome
2. Food & Beverage Nutrition Fortifier
Added to dairy, functional drinks, infant formula, health food to supplement vitamin B12 intake
3. Animal Feed Additive
Feed premix for livestock, poultry, aquaculture; improves animal growth, reproduction and hematopoiesis
4. Microbiological Culture Medium
Essential growth factor for lactic acid bacteria, propionibacteria, certain eukaryotic cell culture
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 68-19-9 |
| Molecular Formula | C63H88CoN14O14P |
| Appearance | Uniform dark red crystal powder without fading impurities |
| HPLC Purity | Pharma Grade ≥98.0%, Food Grade ≥96.0% |
| Water Content (KF) | ≤12.00% |
| Residue on Ignition | 4.5% ~ 5.5% (cobalt salt ash) |
| Single Maximum Unknown Impurity | ≤0.50% |
| Cobalt Content | 4.0% ~ 4.5% |
| Heavy Metals (Pb) | ≤10 ppm |
| Microbiological Limit | No pathogenic bacteria, meets injection/food standards |
| Packaging | 1g/10g amber light-proof glass vial, 100g/1kg vacuum aluminum foil bag, 25kg PE lined light-proof fiber drum |
| Storage Condition | Hermetically sealed cool warehouse 2–8 ℃, complete light shielding, isolate alkaline chemicals, oxidants and heavy metal raw materials |
| Transportation Requirement | Highly light-sensitive hygroscopic vitamin powder, cold-chain light-proof fully sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed refrigerated storage |
Safety Warning
Low-toxic cobalt complex vitamin powder. Dust irritates eyes and respiratory tract; long-term excessive intake may cause mild skin allergic reaction. All operations carried out in light-proof ventilated fume hood with dust-proof respirator, amber protective goggles and nitrile gloves. Strictly avoid light exposure and mixing with alkaline substances to prevent decomposition. Waste liquid diluted before discharge; solid waste classified as general biochemical nutrition raw material waste.
...
Product
