Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Tylosin
1. Basic Information
Name: Tylosin
Alias: Tylosin base, Tylosin A, Macrolide veterinary antibiotic
CAS No.: 1401-69-0
Molecular Formula: C??H??NO??
Molecular Weight: 916.10
Category: Macrolide veterinary antibiotic API, livestock and poultry antibacterial raw material, animal feed additive, mycoplasma specific inhibitor
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to pale yellow crystalline powder
- Odor: Faint characteristic fermentation antibiotic odor, bitter taste
- Solubility: Slightly soluble in water; soluble in methanol, ethanol, acetone, dichloromethane; hardly soluble in alkane solvents
- Melting Point: 128–132 ℃
- Specific Rotation [α]???: ?46° ~ ?52° (c=2, methanol)
- Density (predicted): 1.23 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous property: Weakly alkaline aqueous solution; unstable under strong acidic conditions, easy to degrade and lose activity
Chemical Properties
- Molecular structure: 16-membered macrolide ring, containing deoxyaminosugar and mycinose side chains, multiple hydroxyl groups and ether bonds
- Antibacterial mechanism: Inhibits bacterial protein synthesis by binding to ribosome 50S subunit, highly effective against Gram-positive bacteria and mycoplasma
- Acid sensitivity: Rapid hydrolysis of glycosidic bonds under low pH, sharp decline in antibacterial activity; stable in neutral and weakly alkaline environments
- Esterification reaction: Hydroxyl groups can form tartrate, phosphate, acetate salts to improve water solubility for injection preparations
- Thermal stability: Stable below 60 ℃; high temperature above 100 ℃ accelerates decomposition
- Photostability: Light-sensitive; long-term UV irradiation darkens powder and reduces titer
- Compatibility: Compatible with neutral carriers, weak alkaline auxiliary materials; incompatible with strong acid, oxidants, penicillin, lincomycin
3. Main Application Fields
1. Veterinary Antibacterial API (Core Application)
Raw material for oral powder, injection, soluble powder; treats mycoplasma pneumonia, swine dysentery, poultry chronic respiratory disease in pigs, chickens, cattle, sheep
2. Feed Additive Growth Promoter
Low-dose addition to livestock and poultry feed, inhibits intestinal harmful bacteria, improves feed conversion rate and growth performance
3. Animal Husbandry Biocontrol Agent
Preventive medication for farm respiratory bacterial mixed infection, widely used in large-scale breeding farms
4. Microbiological Research Reagent
Selective antibiotic for cell culture, mycoplasma elimination reagent to remove mycoplasma contamination in cell lines
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 1401-69-0 |
| Molecular Formula | C??H??NO?? |
| Appearance | Uniform pale yellow crystal without dark impurities |
| HPLC Titer | Veterinary API Grade ≥900 μg/mg |
| Water Content (KF) | ≤4.00% |
| Residue on Ignition | ≤1.00% |
| Single Related Impurity | ≤3.00% |
| Heavy Metals (Pb) | ≤10 ppm |
| Microbiological Limit | No pathogenic bacteria |
| Packaging | 1kg/5kg light-proof aluminum foil vacuum bag, 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse 2–25 ℃, full light shielding, isolate acidic raw materials |
| Transportation Requirement | Slightly hygroscopic light-sensitive antibiotic powder, moisture-proof sealed packaging, separate from food and human medicine |
| Shelf Life | 36 months under nitrogen vacuum sealed storage |
Safety Warning
Irritant antibiotic powder. Dust irritates eyes, nasal tract and respiratory tract; long-term repeated inhalation easily induces drug allergic rhinitis and skin dermatitis. All operations must be carried out in ventilated fume hood with dust-proof respirator, splash-proof goggles and chemical-resistant nitrile gloves. Avoid mixing with strong acid to prevent degradation. Waste liquid neutralized before discharge; solid waste classified as veterinary antibiotic hazardous waste disposed by licensed professional institutions. Strictly control medication withdrawal period for edible animals.
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