Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Semaglutide
1. Basic Information
Name: Semaglutide
Alias: Sermaglutide, GLP?1 analog long?acting hypoglycemic polypeptide
CAS No.: 910463-68-2
Molecular Formula: C???H???N??O??S
Molecular Weight: 4113.58
Category: Long-acting GLP?1 receptor agonist polypeptide API, diabetes treatment raw material, weight-loss drug active pharmaceutical ingredient, peptide biotech raw material
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white amorphous lyophilized powder
- Odor: Odorless, faint polypeptide slight bitter taste
- Solubility: Freely soluble in dilute aqueous acid, dilute buffer solution; soluble in methanol; slightly soluble in ethanol; insoluble in acetone, ether, alkanes, aromatic solvents
- Melting Point: Decomposes above 220 ℃, no clear melting point
- Specific Rotation [α]???: ?18° ~ ?24° (c=1, dilute acetic acid)
- Density (predicted): 1.32 g/cm3
- Hygroscopy: Strongly hygroscopic, easy to absorb moisture and agglomerate under high humidity
- Aqueous property: Amphoteric polypeptide, stable pH range 4.0–7.5; severe degradation under strong acid, strong alkali, high temperature
Chemical Properties
- Molecular structure: Modified human GLP?1 polypeptide, fatty acid side chain conjugated at lysine residue, realizes albumin binding and ultra-long half-life; contains multiple peptide bonds, cysteine sulfhydryl, multiple chiral amino acid centers
- Enzymatic hydrolysis susceptibility: Peptide bonds easily broken by protease, leading to loss of hypoglycemic activity
- Oxidation sensitivity: Methionine, cysteine residues oxidize under oxygen/UV light, forming oxidized impurities and reducing efficacy
- Fatty acid side chain stability: Amide linkage between fatty acid and lysine stable in neutral environment; hydrolyzes under heating strong acid to release free fatty acid
- Thermal stability: Stable below 60 ℃; boiling or high-temperature sterilization causes irreversible polypeptide denaturation
- Photostability: Extremely light-sensitive; UV irradiation accelerates oxidation, powder turns yellow and related impurities rise sharply
- Compatibility: Compatible with neutral phosphate/acetate buffer, mannitol, trehalose lyoprotectants; incompatible with strong oxidants, heavy metal ions, concentrated acid/alkali
3. Main Application Fields
1. Type 2 Diabetes Treatment API (Core Application)
Raw material for subcutaneous injection formulations; long-acting GLP?1 agonist, lowers blood glucose, reduces glycosylated hemoglobin, protects pancreatic β-cells, administered once weekly
2. Chronic Weight Management Drug Raw Material
Approved for obesity/overweight adjuvant treatment; suppresses appetite, delays gastric emptying, reduces calorie intake and body weight
3. Cardiovascular Risk Reduction Preparation
Clinical adjuvant medication for diabetic patients with cardiovascular complications, reduces major adverse cardiovascular event risk
4. Biochemical Research Reagent
GLP?1 receptor positive control compound for cell-level drug screening and receptor binding activity evaluation
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 910463-68-2 |
| Molecular Formula | C???H???N??O??S |
| Appearance | Uniform white lyophilized powder without yellow discoloration |
| HPLC Purity | Injection Grade ≥98.5% |
| Water Content (KF) | ≤3.00% |
| Residue on Ignition | ≤0.50% |
| Single Maximum Related Peptide Impurity | ≤0.30% |
| Total Impurities | ≤1.50% |
| Chiral Isomer & Racemization Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤5 ppm |
| Microbial Limit | Sterile raw material, no bacteria/fungi/mycoplasma |
| Packaging | Sealed amber light-proof glass vial filled with nitrogen, aluminum foil vacuum outer packaging; bulk 1kg/5kg PE lined light-proof freeze-drying fiber drum |
| Storage Condition | Hermetically sealed constant temperature warehouse 2–8 ℃, complete light shielding, isolate oxidants, heavy metal raw materials and humid air |
| Transportation Requirement | Ultra-light-sensitive, strongly hygroscopic polypeptide raw material, cold-chain refrigerated full sealed packaging, avoid sunlight and high temperature |
| Shelf Life | 36 months under nitrogen vacuum sealed refrigerated storage |
Safety Warning
Biological polypeptide irritant powder. Dust inhalation irritates respiratory tract and may induce allergic reactions; skin/mucous contact may cause local redness and itching. All operations must be carried out in sterile light-proof fume hood with dust-proof biological respirator, amber UV-blocking goggles and thick peptide-resistant nitrile gloves. Strictly avoid light exposure, high temperature and contact with oxidants/heavy metals. Waste liquid treated with high-temperature inactivation before discharge; solid waste classified as pharmaceutical polypeptide hazardous waste for professional incineration disposal. Operators with protein allergies must avoid all contact.
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