Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
1. Basic Information
Name: 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Alias: Desalkylflurazepam; 7-Chloro-5-(2-fluorophenyl)-1,4-benzodiazepin-2-one
CAS No.: 2886-65-9
Molecular Formula: C15H10ClFN2O
Molecular Weight: 288.70
Category: Benzodiazepine pharmaceutical intermediate, anxiolytic/hypnotic drug core building block, controlled psychoactive raw material precursor
2. Physical and Chemical Properties
Physical Properties
- Appearance: Off-white to pale beige crystalline powder
- Odor: Faint mild heterocyclic odor, tasteless solid
- Solubility: Soluble in DCM, THF, DMF, hot ethanol, toluene; slightly soluble in cold methanol; insoluble in water, hexane, petroleum ether
- Melting Point: 212–216 ℃
- Density (predicted): 1.39 g/cm3
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Aqueous property: Neutral solid, stable in neutral water at room temperature; lactam ring hydrolyzes slowly under strong acid/strong alkali heating
Chemical Properties
- Molecular structure: 1,4-benzodiazepine seven-membered nitrogen heterocycle, 7-position chloro substitution, 5-position ortho-fluorophenyl, cyclic lactam carbonyl at C2; parent skeleton of flurazepam, alprazolam series sedative drugs
- Lactam reactivity: N1 nitrogen can undergo alkylation to introduce aminoalkyl side chains for finished benzodiazepine APIs
- Aromatic halogen stability: Aryl-Cl and aryl-F stable under neutral/weak acid; high-temperature strong alkali triggers dehalogenation
- Photodegradation: UV light induces heterocycle oxidation, powder turns tan, generates unknown related impurities
- Thermal stability: Stable below 200 ℃; prolonged heating above melting point causes slight decomposition and discoloration
- Redox compatibility: Inert to mild reducing agents; reacts with strong oxidants to produce nitrogen oxide and chlorinated aromatic byproducts
- Compatibility: Compatible with anhydrous aprotic solvents; incompatible with concentrated strong alkali, strong oxidants, heavy metal ions
3. Main Application Fields
1. Sedative & Hypnotic API Key Intermediate (Core Application)
Parent skeleton for synthesizing flurazepam and other benzodiazepine anxiolytic, sleep-aid pharmaceuticals; N-alkylation modifies the molecule to obtain finished active pharmaceutical ingredients
2. Central Nervous System Drug Synthetic Building Block
Substrate for developing new generation short-acting benzodiazepine tranquilizers and anti-convulsant drugs
3. Pharmacological Research Reference Standard
Positive control compound for GABA-A receptor binding screening in neuropharmacology labs
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 2886-65-9 |
| Molecular Formula | C15H10ClFN2O |
| Appearance | Uniform off-white crystal without dark brown impurities |
| HPLC Purity | Pharma Intermediate Grade ≥98.5% |
| Melting Point | 212–216 ℃ |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.80% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber light-proof aluminum foil vacuum bag; bulk 1kg/5kg light-shield PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse 2–25 ℃, full light shielding, isolate alkaline chemicals and oxidants; strict controlled storage per psychoactive precursor regulations |
| Transportation Requirement | Light-sensitive benzodiazepine controlled intermediate, sealed light-proof packaging, separate from food, daily chemicals and strong corrosives; comply with national controlled precursor transport rules |
| Shelf Life | 36 months under nitrogen vacuum sealed storage |
Safety Warning
Irritant psychoactive precursor crystalline powder. Dust severely irritates eyes, nasal and respiratory tract; repeated inhalation may cause drowsiness, dizziness. Skin/mucous contact triggers redness and itching. Strictly implement controlled chemical management procedures. All operations in light-proof fully ventilated fume hood with dust-proof respirator, UV-blocking splash goggles and thick chemical-resistant nitrile gloves. Avoid light exposure, high temperature and mixing with strong alkali/oxidants. Waste liquid treated with oxidative degradation before discharge; solid waste classified as controlled psychotropic organic hazardous waste, disposed by qualified licensed institutions. Strict record-keeping for all purchase, usage and inventory.
...
Product
