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(R)-3-Amino-1-butanol
1. Basic Information
Name: (R)-3-Amino-1-butanol
Alias: (R)-3-Aminobutan-1-ol
CAS No.: 61477-40-5
Molecular Formula: C4H11NO
Molecular Weight: 89.14
Category: Chiral amino alcohol fine chemical intermediate, pharmaceutical chiral building block, asymmetric synthesis raw material, catalyst ligand precursor
2. Physical and Chemical Properties
Physical Properties
- Appearance: Colorless transparent viscous liquid
- Odor: Typical mild amine irritating odor
- Solubility: Fully miscible with water, methanol, ethanol, isopropanol; soluble in THF, dichloromethane; slightly soluble in toluene; insoluble in alkane solvents
- Boiling Point: 178–182 ℃
- Density (20℃): 0.925–0.935 g/cm3
- Refractive Index n?2?: 1.448–1.452
- Hygroscopy: Strongly hygroscopic, rapidly absorbs water and carbon dioxide from air
- Aqueous property: Aqueous solution strongly alkaline, pH＞11; stable under neutral condition, reacts with CO? to form carbonate salt
Chemical Properties
- Molecular structure: Chiral carbon at C3, carries primary amino group and terminal hydroxyl group, dual functional groups of -NH2 and -OH, single chiral center
- Amine characteristic reaction: Amino group undergoes acylation, alkylation, diazotization, condensation with carbonyl compounds to construct chiral heterocyclic drug skeletons
- Hydroxyl derivatization: Hydroxyl group can esterify, etherify, halogenate to introduce various side chains
- Chiral resolution & ligand: Used as chiral resolving agent for acidic compounds; coordination ligand for asymmetric catalytic reactions
- Carbon dioxide absorption: Exposed to air readily absorbs CO2 to generate white solid amine carbonate, reducing product purity
- Thermal stability: Stable below 150 ℃; long-time high temperature heating triggers intramolecular cyclization to form pyrrolidine derivatives
- Photostability: Slightly light-sensitive; long-term light exposure turns pale yellow
- Compatibility: Compatible with alcohols, esters, neutral aprotic solvents; incompatible with strong acids, acid anhydrides, halocarbons, heavy metal ions
3. Main Application Fields
1. Chiral Pharmaceutical Intermediate (Core Application)
Key chiral fragment for synthesizing central nervous system drugs, antiviral small-molecule APIs; used to construct chiral amine side chains of target molecules
2. Asymmetric Organic Synthesis Reagent
Chiral ligand and chiral auxiliary for asymmetric reduction, cyclization reaction screening
3. Fine Chemical Chiral Auxiliary
Raw material for chiral separating agent, chromatographic chiral stationary phase precursor
4. Biochemical Research Reagent
Chiral standard sample for chiral HPLC separation verification
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 61477-40-5 |
| Molecular Formula | C4H11NO |
| Appearance | Colorless clear viscous liquid without turbidity |
| GC Purity | Chiral Synthesis Grade ≥99.0% |
| Enantiomeric Excess (ee) | ≥99.0% |
| Water Content (KF) | ≤0.20% |
| Chroma (APHA) | ≤30 |
| Amine Carbonate Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-sealed amber glass bottle, 200kg nitrogen-filled galvanized iron drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, full light shielding, isolate air, carbon dioxide and acidic raw materials |
| Transportation Requirement | Strongly hygroscopic alkaline chiral amine liquid, nitrogen sealed packaging, separate from acid, oxidants and food chemicals |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Corrosive alkaline chiral amine liquid. Vapor severely irritates eyes, nasal tract and respiratory tract; direct skin contact causes erythema, burning pain and chemical dermatitis. All operations must be carried out in fully ventilated fume hood with gas-proof respirator, anti-splash chemical goggles and alkali-resistant thick nitrile gloves. Strictly avoid contact with air, acidic substances and carbon dioxide. Waste liquid neutralized with dilute acid before discharge; residual liquid classified as alkaline chiral organic hazardous waste for professional disposal.
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