Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
1. Basic Information
Name: 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
Alias: 2-(Chloromethyl)-3,5-dimethyl-4-methoxypyridinium chloride
CAS No.: 86604-75-3
Molecular Formula: C9H13Cl2NO
Molecular Weight: 222.11
Category: Pyridine heterocyclic pharmaceutical intermediate, proton pump inhibitor raw material, active benzyl chloride building block
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Slight pungent alkyl chloride irritating odor
- Solubility: Freely soluble in water, methanol, ethanol; soluble in DMF; slightly soluble in acetone; insoluble in toluene, hexane, ethyl acetate
- Melting Point: 136–142 ℃ (decomposes)
- Density (predicted): 1.24 g/cm3
- Hygroscopy: Strongly hygroscopic, absorbs moisture and agglomerates under high humidity
- Aqueous property: Aqueous solution strongly acidic pH 2.0–4.0; chloromethyl group prone to hydrolysis in hot water
Chemical Properties
- Molecular structure: Pyridine ring with 3,5-dimethyl, 4-methoxy, 2-chloromethyl substitution, hydrochloride salt form; highly reactive benzyl chloromethyl functional group
- SN2 nucleophilic substitution: The chloromethyl (-CH2Cl) is highly active, reacts with thiols, amines, alcohols to form sulfide, amine, ether derivatives; core intermediate for omeprazole series PPI drugs
- Hydrolysis risk: Hot water / alkaline environment hydrolyzes chloromethyl into hydroxymethyl impurity, reduces product activity
- Salt dissociation: Dissolves in polar solvents to release pyridinium cation and chloride ion
- Thermal stability: Stable below 60 ℃; above 100 ℃ decomposes to release hydrogen chloride gas
- Photostability: Light-sensitive; UV irradiation accelerates decomposition, powder turns yellow
- Compatibility: Compatible with anhydrous low-polar aprotic solvents; incompatible with strong alkali, amines, oxidants, water at high temperature
3. Main Application Fields
1. Proton Pump Inhibitor API Intermediate (Core Application)
Key raw material for synthesis of omeprazole, esomeprazole; undergoes thioether condensation with mercaptobenzimidazole to prepare gastric acid inhibiting drugs
2. Other Pyridine-Series Heterocyclic Drug Building Block
Used for synthesis of anti-ulcer, digestive system small-molecule pharmaceuticals
3. Organic Synthesis Nucleophilic Substrate
Active alkylating reagent for lab heterocyclic synthesis research
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 86604-75-3 |
| Molecular Formula | C9H13Cl2NO |
| Appearance | Uniform white crystal without yellow discoloration |
| HPLC Purity | Pharma Intermediate Grade ≥98.5% |
| Melting Point | 136–142 ℃ |
| Water Content (KF) | ≤1.00% |
| Residue on Ignition | ≤0.10% |
| Hydrolysis Impurity (Hydroxymethyl pyridine) | ≤0.20% |
| Single Maximum Related Impurity | ≤0.15% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber light-proof aluminum foil vacuum bag; bulk 25kg PE lined light-proof fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse 2–25 ℃, full light shielding, isolate humid air, alkaline materials and amines |
| Transportation Requirement | Strongly hygroscopic light-sensitive alkyl chloride pyridine salt, fully sealed moisture-proof light-blocking packaging, separate from alkaline chemicals and food |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Highly irritating chlorinated pyridinium salt powder. Dust severely irritates eyes, nasal cavity, throat and respiratory tract; skin contact causes burning redness and allergic dermatitis; hydrolysis releases irritating HCl vapor. All operations in fully ventilated fume hood with gas dust respirator, UV-blocking splash goggles and thick chemical-resistant nitrile gloves. Strictly avoid moisture, light, high temperature and contact with alkaline substances. Waste liquid neutralized with sodium carbonate solution before discharge; solid waste classified as halogen-containing pharmaceutical hazardous waste for professional incineration disposal.
...
Product
