Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Thymopentin
1. Basic Information
Name: Thymopentin
Alias: Arg-Lys-Asp-Val-Tyr; Thymopoietin pentapeptide
CAS No.: 69558-55-0
Molecular Formula: C30H49N9O9
Molecular Weight: 679.77
Category: Synthetic immunomodulatory polypeptide API, immune-enhancing pharmaceutical raw material, biochemistry research reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white lyophilized amorphous powder
- Odor: Odorless, slight polypeptide bitter taste
- Solubility: Freely soluble in water, dilute acetic acid buffer; soluble in methanol; slightly soluble in ethanol; insoluble in acetone, ethyl acetate, alkanes
- Melting Point: Decomposes above 210 ℃, no distinct melting point
- Density (predicted): 1.33 g/cm3
- Hygroscopy: Strongly hygroscopic, easy to absorb moisture and agglomerate under high humidity
- Aqueous property: Amphoteric polypeptide, stable pH range 4.0–7.0; peptide bonds degrade rapidly under strong acid, strong alkali and high temperature
Chemical Properties
- Molecular structure: Linear pentapeptide composed of arginine, lysine, aspartic acid, valine, tyrosine; multiple peptide bonds, amino, carboxyl, phenolic hydroxyl groups
- Immunological activity mechanism: Simulates thymopoietin function, regulates T lymphocyte differentiation and maturation, enhances human cellular immunity
- Enzymatic degradation susceptibility: Susceptible to protease hydrolysis, resulting in loss of immune activity
- Oxidation sensitivity: Tyrosine phenolic hydroxyl group oxidizes under UV light and heavy metal ions to form yellow oxidation impurities
- Thermal stability: Stable below 60 ℃; heating above 80 ℃ triggers irreversible polypeptide denaturation and fragmentation
- Photostability: Extremely light-sensitive; long-term light exposure increases related impurities and reduces biological potency
- Compatibility: Compatible with neutral weak acid buffer, mannitol, trehalose protective agents; incompatible with strong oxidants, heavy metal salts, concentrated acid/alkali
3. Main Application Fields
1. Immune Regulation Injection API (Core Application)
Raw material for thymopentin injection; clinically used for hypoimmune diseases, tumor adjuvant therapy, recurrent infection caused by low immunity
2. Immunology Laboratory Research Reagent
Positive control compound for T cell proliferation, immune cell activity screening experiments
3. Compound Immunomodulatory Preparations
Combined with vitamins and other immune auxiliary raw materials for adjuvant immune conditioning products
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 69558-55-0 |
| Molecular Formula | C30H49N9O9 |
| Appearance | Uniform white freeze-dried powder without yellow discoloration |
| HPLC Purity | Injection Sterile Grade ≥98.5% |
| Water Content (KF) | ≤3.00% |
| Residue on Ignition | ≤0.50% |
| Single maximum peptide impurity | ≤0.30% |
| Total related substances | ≤1.50% |
| Heavy Metals (Pb) | ≤5 ppm |
| Microbial Limit | Sterile raw material, free of bacteria, fungi and mycoplasma |
| Packaging | Nitrogen-filled amber light-proof glass vials; bulk 1kg/5kg light-shield PE lined freeze-drying fiber drums |
| Storage Condition | Hermetically sealed constant temperature warehouse 2–8 ℃, full light shielding, isolate humid air, oxidants and heavy metal raw materials |
| Transportation Requirement | Ultra-light-sensitive hygroscopic polypeptide raw material, cold-chain light-proof sealed packaging, avoid high temperature and sunlight irradiation |
| Shelf Life | 36 months under nitrogen vacuum sealed refrigerated storage |
Safety Warning
Allergenic polypeptide irritant powder. Dust inhalation irritates respiratory tract and may induce protein allergic reactions; skin and eye contact causes local redness and stinging. All operations must be carried out in light-proof sterile fume hood with biological dust respirator, UV-blocking splash goggles and peptide-resistant thick nitrile gloves. Strictly avoid light exposure, high temperature and contact with oxidants/heavy metals. Waste liquid treated with high-temperature inactivation before discharge; solid waste classified as pharmaceutical polypeptide hazardous waste for professional incineration disposal. Operators with protein allergies are prohibited from contact.
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