Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1,2-Dimethoxybenzene
1. Basic Information
Name: 1,2-Dimethoxybenzene
Alias: Veratrole
CAS No.: 91-16-7
Molecular Formula: C8H10O2
Molecular Weight: 138.16
Category: Aromatic ether fine chemical raw material, spice intermediate, pharmaceutical synthetic building block, organic synthesis substrate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Colorless transparent oily liquid or low melting crystalline solid
- Odor: Mild aromatic herbal fragrance
- Solubility: Soluble in ethanol, methanol, acetone, DCM, toluene; slightly soluble in hot water; insoluble in cold water, aliphatic alkanes
- Melting Point: 20–22 ℃
- Boiling Point: 206–208 ℃
- Density (20℃): 1.084–1.088 g/cm3
- Refractive Index nD20: 1.532–1.534
- Hygroscopy: Non-hygroscopic
- Aqueous property: Neutral aromatic ether, stable in neutral aqueous solution at room temperature
Chemical Properties
- Molecular structure: Ortho-dimethoxy substituted benzene ring, two electron-donating methoxy groups, easy to undergo electrophilic aromatic substitution
- Electrophilic substitution activity: Methoxy activates benzene ring, suitable for nitration, halogenation, acylation to prepare drug and spice derivatives
- Ether bond stability: Stable under neutral/weak acid conditions; strong concentrated acid high temperature will break ether bond to generate catechol
- Thermal stability: Stable below 180 ℃; long-time heating above boiling point has slight oxidative discoloration
- Photostability: Slightly light-sensitive; long-term UV exposure turns pale yellow
- Compatibility: Compatible with most organic solvents; incompatible with concentrated strong acid, strong oxidants
3. Main Application Fields
1. Synthetic Spice Intermediate (Core Application)
Raw material for synthesis of high-grade floral, woody spices; widely used in daily flavor and food essence formulation
2. Pharmaceutical Heterocyclic Intermediate
Precursor for synthesis of central nervous system drugs, anti-inflammatory and antibacterial small molecule APIs
3. Organic Synthesis Laboratory Reagent
Standard substrate for Friedel-Crafts acylation, electrophilic substitution reaction research
4. Electrochemical & Polymer Auxiliary
Organic solvent additive for special polymer synthesis and battery electrolyte auxiliary
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 91-16-7 |
| Molecular Formula | C8H10O2 |
| Appearance | Colorless clear liquid, no turbidity or precipitate |
| GC Purity | Spice/Pharmaceutical Grade ≥99.0% |
| Water Content (KF) | ≤0.10% |
| Chroma (APHA) | ≤30 |
| Residue on Ignition | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Amber light-proof glass bottle; bulk 200kg sealed iron drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, light shielding, isolate strong oxidants and concentrated acid |
| Transportation Requirement | Slightly light-sensitive aromatic ether liquid, conventional sealed packaging, separate from strong corrosive goods |
| Shelf Life | 24 months under nitrogen sealed storage |
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