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Glucose pentaacetate
1. Basic Information
Name: Glucose pentaacetate
Alias: Penta-O-acetyl-D-glucose
CAS No.: 604-68-2
Molecular Formula: C14H18O9
Molecular Weight: 330.29
Category: Carbohydrate protected intermediate, pharmaceutical raw material, fine chemical synthesis substrate, chromatographic reference standard
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, faint acetic ester mild smell
- Solubility: Soluble in chloroform, dichloromethane, hot ethanol, acetone; slightly soluble in cold ethanol; insoluble in water, petroleum ether, hexane
- Melting Point: 112–114 ℃
- Specific Rotation [α]D20: +40° ~ +44° (c=5, CHCl3)
- Density (predicted): 1.28 g/cm3
- Hygroscopy: Non-hygroscopic under normal storage environment
- Aqueous property: Stable in neutral cold water; ester groups hydrolyze under strong acid/alkali heating to generate glucose and acetic acid
Chemical Properties
- Molecular structure: All five hydroxyl groups of D-glucose fully acetylated, fully protected sugar derivative with stable six-membered pyranose ring
- Protecting group characteristic: Acetyl groups can be selectively or fully deacetylated under acidic or alkaline conditions to recover glucose hydroxyl groups
- Glycosylation reactivity: Classic raw material for glycosylation reaction, can prepare glycoside, glycosamine and other carbohydrate drug intermediates
- Thermal stability: Stable below 100 ℃; long-time heating above melting point causes partial deacetylation discoloration
- Photostability: Good light resistance, no obvious discoloration under long-term light storage
- Compatibility: Compatible with most anhydrous organic solvents; incompatible with concentrated strong acid, strong alkaline aqueous solution at high temperature
3. Main Application Fields
1. Carbohydrate Pharmaceutical Intermediate (Core Application)
Key precursor for synthesizing glycoside drugs, antiviral nucleoside sugar fragments, antibacterial glycoside derivatives
2. Organic Synthesis Research Reagent
Standard protected sugar substrate for glycosylation, sugar modification, carbohydrate chemistry laboratory research
3. Chromatography Standard Reference
HPLC reference substance for sugar derivative detection, carbohydrate qualitative and quantitative analysis
4. Flavor & Polymer Auxiliary
Low-odor ester additive for special polymer and essence formulation
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 604-68-2 |
| Molecular Formula | C14H18O9 |
| Appearance | Uniform white crystal without yellow discoloration |
| HPLC Purity | Synthetic Grade ≥98.5%, Standard Grade ≥99.5% |
| Melting Point | 112–114 ℃ |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Specific Rotation | +40 ~ +44 ° |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Light-proof aluminum foil vacuum bag; bulk 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, isolate strong acid and alkaline raw materials |
| Transportation Requirement | Non-hygroscopic sugar ester crystal, conventional moisture-proof sealed packaging |
| Shelf Life | 24 months under fully sealed storage |
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