Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
5-Methoxyindole
1. Basic Information
Name: 5-Methoxyindole
Alias: 5-Methoxy-1H-indole
CAS No.: 1006-94-6
Molecular Formula: C9H9NO
Molecular Weight: 147.17
Category: Indole heterocyclic pharmaceutical intermediate, organic synthetic building block, biochemical research reagent, fine chemical raw material
2. Physical and Chemical Properties
Physical Properties
- Appearance: Off-white to pale beige crystalline powder
- Odor: Faint characteristic indole odor
- Solubility: Soluble in ethanol, methanol, dichloromethane, chloroform, THF, toluene; slightly soluble in hot water; insoluble in cold water and aliphatic alkanes
- Melting Point: 56–58 °C
- Predicted Density: 1.148 g/cm3
- Hygroscopy: Non-hygroscopic under normal storage conditions
- Aqueous property: Neutral aromatic heterocycle, stable in neutral cold water at ambient temperature
Chemical Properties
- Molecular structure: Indole parent ring with methoxy substitution at the 5-position; contains pyrrole NH and electron-donating methoxy group, highly active for electrophilic substitution
- Electrophilic reactivity: The indole 3-position readily undergoes halogenation, acylation, Mannich and coupling reactions for constructing drug skeletons
- NH reactivity: Pyrrole nitrogen can be alkylated, acylated or protected to generate N-substituted indole derivatives
- Photostability: Light-sensitive; long-term UV irradiation causes discoloration and oxidation impurities
- Thermal stability: Stable below 50 °C; prolonged heating above melting point triggers oxidative darkening
- Compatibility: Compatible with anhydrous polar aprotic solvents; incompatible with strong oxidants and concentrated strong acid under heating
3. Main Application Fields
1. Pharmaceutical Heterocyclic Intermediate (Core Application)
Key precursor for synthesizing serotonin receptor modulators, anti-depressant, anti-tumor and anti-inflammatory small-molecule APIs
2. Organic Synthesis Laboratory Reagent
Standard indole substrate for cross-coupling, cyclization and heterocyclic derivatization research
3. Biochemical Research Tool
Structural analog of endogenous indoleamine neurotransmitters for receptor binding mechanism study
4. Dye & Fluorescent Material Intermediate
Precursor for indole-based fluorescent probes and organic luminescent material monomers
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 1006-94-6 |
| Molecular Formula | C9H9NO |
| Appearance | Uniform off-white crystalline powder without dark discoloration |
| HPLC Purity | Pharmaceutical Grade ≥99.0%, Research Grade ≥99.5% |
| Melting Point | 56–58 °C |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.05% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Light-proof aluminum foil vacuum bag; bulk 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C, full light shielding, separate from strong oxidants |
| Transportation Requirement | Light-sensitive indole crystalline powder, moisture-proof sealed packaging, away from oxidizing hazardous goods |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
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