Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Aminothiazole
1. Basic Information
Name: 2-Aminothiazole
Alias: 2-Thiazolamine
CAS No.: 96-50-4
Molecular Formula: C3H4N2S
Molecular Weight: 100.14
Category: Sulfur-nitrogen heterocyclic pharmaceutical intermediate, pesticide raw material, dyestuff intermediate, analytical reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to pale yellow crystalline powder
- Odor: Slight heterocyclic amine odor
- Solubility: Soluble in water, ethanol, methanol, acetone; slightly soluble in ether; insoluble in benzene, aliphatic hydrocarbons
- Melting Point: 90–93 °C
- Predicted Density: 1.32 g/cm3
- Hygroscopy: Moderately hygroscopic, easy to agglomerate under high humidity
- Aqueous property: Weak alkaline aqueous solution; forms soluble salts when reacted with inorganic acids
Chemical Properties
- Molecular structure: Thiazole ring with amino substitution at C2 position; amino group and thiazole ring both have high chemical activity
- Amino group reactivity: Capable of diazotization, acylation, alkylation, condensation reactions to construct various drug skeletons
- Ring reactivity: Thiazole ring undergoes halogenation, nitration and electrophilic substitution under mild conditions
- Photostability: Highly light-sensitive; prolonged UV exposure turns powder dark brown and generates oxidation impurities
- Thermal stability: Stable below 80 °C; decomposes above melting point to release toxic sulfur-containing volatile gas
- Compatibility: Compatible with polar protic/aprotic solvents; incompatible with strong oxidants, concentrated strong acid under heating
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key raw material for synthesizing antibiotics, anti-ulcer drugs, anti-inflammatory and anti-tumor small-molecule APIs
2. Pesticide Intermediate
Precursor for fungicides, insecticides and plant growth regulators with thiazole active structure
3. Dyestuff & Photographic Chemical Auxiliary
Synthetic raw material for azo dyes, color couplers and photosensitive agents
4. Analytical Chemistry Reagent
Chelating reagent for qualitative detection of heavy metal ions in water samples
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 96-50-4 |
| Molecular Formula | C3H4N2S |
| Appearance | Uniform white crystalline powder without dark discoloration |
| HPLC Purity | Pharmaceutical Grade ≥99.0%, Industrial Grade ≥98.0% |
| Melting Point | 90–93 °C |
| Water Content (KF) | ≤0.50% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Light-proof aluminum foil vacuum bag; bulk 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C, full light shielding, separate from strong oxidants |
| Transportation Requirement | Light-sensitive hygroscopic heterocyclic powder, moisture-proof sealed packaging, isolated from oxidizing dangerous goods |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
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