Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Chloro-3-cyanopyridine
1. Basic Information
Name: 2-Chloro-3-cyanopyridine
Alias: 2-Chloronicotinonitrile
CAS No.: 6602-54-6
Molecular Formula: C6H3ClN2
Molecular Weight: 138.55
Category: Pyridine heterocyclic pharmaceutical intermediate, fine chemical synthesis building block, agrochemical raw material
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to pale yellow crystalline powder
- Odor: Faint heterocyclic pungent odor
- Solubility: Soluble in dichloromethane, chloroform, THF, toluene, hot ethanol; slightly soluble in cold ethanol; insoluble in water and aliphatic alkanes
- Melting Point: 80–83 °C
- Predicted Density: 1.33 g/cm3
- Hygroscopy: Non-hygroscopic under regular storage environment
- Aqueous property: Neutral aromatic nitrogen heterocycle, stable in neutral cold water at room temperature
Chemical Properties
- Molecular structure: Pyridine ring substituted with chlorine at C2 and cyano group at C3; two highly reactive functional groups for derivatization
- Chlorine reactivity: The ortho-chlorine atom undergoes nucleophilic substitution with amines, alcohols, thiols to construct various drug side chains
- Cyano group reactivity: Cyano can be hydrolyzed to carboxylic acid, reduced to aminomethyl, or cyclized to form nitrogen heterocycles such as tetrazole
- Photostability: Light-sensitive; long-term UV exposure leads to darkening and oxidative impurities
- Thermal stability: Stable below 70 °C; heating above melting point decomposes and releases toxic cyanide and chloride volatile substances
- Compatibility: Compatible with anhydrous aprotic solvents; incompatible with strong oxidants, concentrated strong acid and alkali under heating
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key precursor for synthesizing JAK inhibitors, anti-inflammatory drugs, anti-tumor and central nervous system small-molecule APIs
2. Agrochemical Intermediate
Raw material for preparing pyridine-based fungicides, insecticides and plant growth regulators
3. Organic Synthesis Laboratory Reagent
Standard disubstituted pyridine substrate for nucleophilic substitution and nitrile conversion research
4. Fluorescent Probe Intermediate
Precursor for pyridine-based fluorescent dyes and ion recognition probes
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 6602-54-6 |
| Molecular Formula | C6H3ClN2 |
| Appearance | Uniform white crystalline powder without dark discoloration |
| HPLC Purity | Pharmaceutical Grade ≥99.0%, Industrial Grade ≥98.0% |
| Melting Point | 80–83 °C |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.05% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Light-proof nitrogen-filled aluminum foil vacuum bag; bulk 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C, full light shielding, separated from strong oxidants |
| Transportation Requirement | Light-sensitive chloropyridine crystalline powder, moisture-proof sealed packaging, isolated from oxidizing hazardous goods |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
...
Product
