Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Methoxydienone
1. Basic Information
Name: Methoxydienone
Alias: 13-Ethyl-3-methoxygona-2,5(10)-dien-17-one, Methoxygonadiene, Levonorgestrel Impurity R (EP), Max LMG, Trena
CAS No.: 2322-77-2
EINECS: 219-034-4
MDL No.: MFCD08457893
Molecular Formula: C20H28O2
Molecular Weight: 300.44
Category: Steroid pharmaceutical intermediate, progestogen research reagent, pharmacopoeia impurity reference standard, hormonal chemistry substrate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless steroid solid
- Solubility: Extremely slightly soluble in water (270 μg/L at 20 °C); soluble in chloroform, dichloromethane, hot methanol, ethanol, THF; insoluble in aliphatic alkanes
- Melting Point: 173–177 °C
- Predicted Boiling Point: 448.0 ± 45.0 °C (760 mmHg)
- Predicted Density: 1.09 ± 0.1 g/cm3
- Flash Point: 188.8 °C
- LogP: 4.80
- Hygroscopy: Non-hygroscopic under normal sealed storage
- Aqueous property: Neutral lipophilic steroid; stable in neutral cold water, no spontaneous hydrolysis at ambient temperature
Chemical Properties
- Molecular structure: 19-nortestosterone steroid skeleton with 13β-ethyl group, C3 methoxy substitution and two conjugated double bonds at C2/C5(10), C17 cyclopentanone carbonyl group; fully chiral polycyclic steroid without 17α-alkyl modification
- Core reactivity: Methoxy group can be deprotected to form phenolic hydroxyl group via dienone-phenol rearrangement; C17 ketone undergoes reduction, condensation and derivatization for steroid drug synthesis; conjugated diene enables selective addition and oxidation reactions
- Photostability: Light-sensitive; prolonged UV exposure causes slight yellowing and trace oxidative impurities
- Thermal stability: Stable below 160 °C; heating above melting point triggers slow decomposition of steroid skeleton and diene oxidation
- Chemical compatibility: Compatible with anhydrous aprotic organic solvents; incompatible with strong oxidants, concentrated strong acid and strong alkaline heating conditions
3. Main Application Fields
1. Levonorgestrel Synthetic Key Intermediate (Core Application)
Core precursor for industrial production of levonorgestrel, a widely used progestin oral contraceptive raw material
2. Pharmacopoeia Impurity Reference Standard
EP-specified impurity R reference substance for levonorgestrel API and finished pharmaceutical quality control testing
3. Biochemical Hormone Research Reagent
Laboratory research tool for progestogen, androgen and anti-progesterone receptor binding mechanism studies
4. Steroid Organic Chemistry Research Substrate
Model compound for dienone-phenol rearrangement, steroid side-chain modification and conjugated diene derivatization research
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 2322-77-2 |
| Molecular Formula | C20H28O2 |
| Appearance | Uniform white crystalline powder without discoloration or agglomeration |
| HPLC Purity | Pharmaceutical Intermediate Grade ≥99.0%, Reference Standard Grade ≥99.5% |
| Melting Point | 173–177 °C |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.05% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Light-proof nitrogen-filled aluminum foil vacuum bag; bulk 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse at 2–25 °C, full light shielding, isolated from oxidants, strong acid and alkali |
| Transportation Requirement | Light-sensitive steroid crystalline powder, moisture-proof sealed packaging, separated from corrosive hazardous goods |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
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