Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
5-Aminolevulinic Acid Hydrochloride
1. Basic Information
Name: 5-Aminolevulinic acid hydrochloride
Alias: 5-ALA HCl, 5-Amino-4-oxopentanoic acid hydrochloride
CAS No.: 5451-09-2
Molecular Formula: C?H??ClNO?
Molecular Weight: 167.59
Category: Photodynamic therapy pharmaceutical raw material, plant growth regulator, biochemical research reagent, cosmetic active ingredient
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to pale off-white crystalline powder
- Odor: Slight faint acidic odor
- Solubility: Freely soluble in water and methanol; slightly soluble in ethanol; insoluble in acetone, ethyl acetate and aliphatic hydrocarbons
- Melting Point: 149–153 °C (decomposes)
- Predicted Density: 1.28 ± 0.1 g/cm3
- Hygroscopy: Strongly hygroscopic, rapidly absorbs moisture and deliquesces under high humidity
- Aqueous property: Aqueous solution presents strong acidity; unstable under neutral and alkaline conditions, prone to self-condensation to form porphyrin polymers
Chemical Properties
- Molecular structure: Linear five-carbon molecule containing primary amino group, ketone carbonyl and terminal carboxylic acid, exists as hydrochloride salt form for stable storage
- Biological activity: Endogenous heme precursor; exogenous supplementation induces protoporphyrin IX accumulation in lesion cells, generating singlet oxygen under light irradiation to realize photodynamic ablation
- Condensation characteristic: Amino and ketone groups spontaneously cyclize in neutral/alkaline aqueous solution to form porphyrin impurities, reducing photodynamic activity
- Photostability: Extremely light-sensitive; UV and visible light trigger rapid degradation and pigmentation
- Thermal stability: Stable below 100 °C; heating above melting point decomposes, releasing irritating acidic volatile gas
- Compatibility: Compatible with acidic buffer solutions; incompatible with alkaline substances, oxidants and metal ions
3. Main Application Fields
1. Medical Photodynamic Therapy API Raw Material (Core Application)
Key active pharmaceutical ingredient for topical photodynamic treatment of skin lesions, actinic keratosis and superficial tumors
2. Agricultural Plant Growth Regulator
Promotes chlorophyll synthesis, improves crop photosynthetic efficiency, enhances stress resistance and fruit coloring
3. Biochemical Laboratory Research Reagent
Standard substrate for heme biosynthesis, mitochondrial metabolism and cell phototoxicity research
4. Anti-Aging Cosmetic Additive
Skin care raw material for light-activated anti-oxidation, spot fading and skin rejuvenation products
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 5451-09-2 |
| Molecular Formula | C?H??ClNO? |
| Appearance | Uniform white crystalline powder without yellow discoloration or caking |
| HPLC Purity | Pharmaceutical Grade ≥99.0%, Agricultural Grade ≥98.5% |
| Melting Point | 149–153 °C (decomposed) |
| Water Content (KF) | ≤0.30% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Endotoxin | ≤0.1 EU/mg (Medical Grade) |
| Packaging | Light-proof nitrogen-filled aluminum foil vacuum bag; bulk 25kg PE lined sealed fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse at 2–8 °C, full light shielding, strictly isolated from humid air and alkaline materials |
| Transportation Requirement | Highly hygroscopic light-sensitive amino acid salt powder, moisture-proof sealed packaging, separated from corrosive hazardous goods |
| Shelf Life | 24 months under intact nitrogen vacuum sealed packaging |
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