Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1,3-Benzodioxole
1. Basic Information
Name: 1,3-Benzodioxole
Alias: Benzo-1,3-dioxole, 1,2-Methylenedioxybenzene
CAS No.: 274-09-9
Molecular Formula: C?H?O?
Molecular Weight: 122.12
Category: Aromatic heterocyclic flavor intermediate, pharmaceutical synthetic building block, fine chemical raw material, organic synthesis reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: Colorless transparent oily liquid
- Odor: Mild sweet herbal, root-like natural aroma
- Solubility: Miscible with ethanol, acetone, toluene, dichloromethane, vegetable oils; insoluble in water, glycerin
- Boiling Point: 172–174 °C (760 mmHg)
- Density (20 °C): 1.059–1.063 g/cm3
- Refractive Index nD20: 1.538–1.542
- Flash Point: 62 °C
- Hygroscopy: Non-hygroscopic
- Aqueous property: Neutral oxygen-containing heterocycle; stable in neutral cold water under room temperature
Chemical Properties
- Molecular structure: Benzene ring fused with five-membered methylenedioxy ring, stable cyclic acetal skeleton
- Electrophilic substitution: Methylenedioxy group is strong electron-donating group; benzene ring easily undergoes halogenation, nitration, formylation to create piperonal, helional and drug intermediates
- Acetal ring stability: Stable under neutral/weak alkaline conditions; hydrolyzes under strong acid heating to catechol and formaldehyde
- Photostability: Slightly light-sensitive; long-term UV exposure slowly yellows
- Thermal stability: Stable below 150 °C; overheating generates trace phenolic decomposition impurities
- Compatibility: Compatible with most fragrance solvents and organic synthesis solvents; incompatible with concentrated strong acid and strong oxidants under heating
3. Main Application Fields
1. Synthetic Fragrance Core Intermediate (Core Application)
Key starting material for producing piperonal, helional, safrole, isosafrole; widely used in floral, woody, herbal perfume and daily detergent flavors
2. Pharmaceutical Heterocyclic Intermediate
Skeleton precursor for anti-inflammatory, anti-depressant, anti-parasitic APIs with methylenedioxyphenyl structural fragment
3. Natural Plant Extract Reference Standard
Marker compound for qualitative analysis of camphor, nutmeg, sassafras essential oils
4. Organic Synthesis Laboratory Reagent
Model electron-rich aromatic substrate for electrophilic aromatic substitution research
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 274-09-9 |
| Molecular Formula | C?H?O? |
| Appearance | Clear colorless liquid without suspended precipitate |
| GC Purity | Fragrance Grade ≥99.0%, Synthetic Reagent Grade ≥99.5% |
| Water Content (KF) | ≤0.10% |
| Chroma (APHA) | ≤20 |
| Catechol Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Amber light-proof glass bottle; bulk 200kg lined iron drum nitrogen sealed |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C, light shielding, isolated from strong acid and oxidants |
| Transportation Requirement | Slightly light-sensitive aromatic heterocyclic liquid, general chemical sealed packaging, separated from corrosive hazardous goods |
| Shelf Life | 24 months under nitrogen-sealed storage |
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